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<StructureSection load='3i2n' size='340' side='right'caption='[[3i2n]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
<StructureSection load='3i2n' size='340' side='right'caption='[[3i2n]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3i2n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I2N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3I2N FirstGlance]. <br>
<table><tr><td colspan='2'>[[3i2n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I2N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3I2N FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">WDR92 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3i2n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i2n OCA], [https://pdbe.org/3i2n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3i2n RCSB], [https://www.ebi.ac.uk/pdbsum/3i2n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3i2n ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3i2n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i2n OCA], [https://pdbe.org/3i2n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3i2n RCSB], [https://www.ebi.ac.uk/pdbsum/3i2n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3i2n ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/WDR92_HUMAN WDR92_HUMAN]] Seems to act as a modulator of apoptosis.  
[https://www.uniprot.org/uniprot/DAA10_HUMAN DAA10_HUMAN] Key assembly factor specifically required for the stability of axonemal dynein heavy chains in cytoplasm.[UniProtKB:A8J3F6]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3i2n ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3i2n ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The WD40 domain exhibits a beta-propeller architecture, often comprising seven blades. The WD40 domain is one of the most abundant domains and also among the top interacting domains in eukaryotic genomes. In this review, we will discuss the identification, definition and architecture of the WD40 domains. WD40 domain proteins are involved in a large variety of cellular processes, in which WD40 domains function as a protein-protein or protein-DNA interaction platform. WD40 domain mediates molecular recognition events mainly through the smaller top surface, but also through the bottom surface and sides. So far, no WD40 domain has been found to display enzymatic activity. We will also discuss the different binding modes exhibited by the large versatile family of WD40 domain proteins. In the last part of this review, we will discuss how post-translational modifications are recognized by WD40 domain proteins.
Structure and function of WD40 domain proteins.,Xu C, Min J Protein Cell. 2011 Mar;2(3):202-14. Epub 2011 Apr 6. PMID:21468892<ref>PMID:21468892</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3i2n" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[WD-repeat protein 3D structures|WD-repeat protein 3D structures]]
*[[WD-repeat protein 3D structures|WD-repeat protein 3D structures]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Amaya, M F]]
[[Category: Amaya MF]]
[[Category: Arrowsmith, C H]]
[[Category: Arrowsmith CH]]
[[Category: Bochkarev, A]]
[[Category: Bochkarev A]]
[[Category: Bountra, C]]
[[Category: Bountra C]]
[[Category: Edwards, A M]]
[[Category: Edwards AM]]
[[Category: He, H]]
[[Category: He H]]
[[Category: Li, Z]]
[[Category: Li Z]]
[[Category: Min, J]]
[[Category: Min J]]
[[Category: Ni, S]]
[[Category: Ni S]]
[[Category: Ouyang, H]]
[[Category: Ouyang H]]
[[Category: Structural genomic]]
[[Category: Seitova A]]
[[Category: Seitova, A]]
[[Category: Weigelt J]]
[[Category: Weigelt, J]]
[[Category: Apoptosis]]
[[Category: Sgc]]
[[Category: Transcription]]
[[Category: Wd repeat]]
[[Category: Wd40 repeat]]
[[Category: Wdr92]]
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