3i33: Difference between revisions

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<StructureSection load='3i33' size='340' side='right'caption='[[3i33]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
<StructureSection load='3i33' size='340' side='right'caption='[[3i33]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3i33]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I33 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3I33 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3i33]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I33 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3I33 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3fe1|3fe1]], [[3gdq|3gdq]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HSPA2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3i33 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i33 OCA], [https://pdbe.org/3i33 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3i33 RCSB], [https://www.ebi.ac.uk/pdbsum/3i33 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3i33 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3i33 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i33 OCA], [https://pdbe.org/3i33 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3i33 RCSB], [https://www.ebi.ac.uk/pdbsum/3i33 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3i33 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/HSP72_HUMAN HSP72_HUMAN]] In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage.  
[https://www.uniprot.org/uniprot/HSP72_HUMAN HSP72_HUMAN] In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C H]]
[[Category: Arrowsmith CH]]
[[Category: Berg, S Van den]]
[[Category: Berglund H]]
[[Category: Berglund, H]]
[[Category: Bountra C]]
[[Category: Bountra, C]]
[[Category: Collins R]]
[[Category: Collins, R]]
[[Category: Edwards AM]]
[[Category: Edwards, A M]]
[[Category: Flodin S]]
[[Category: Flodin, S]]
[[Category: Flores A]]
[[Category: Flores, A]]
[[Category: Graslund S]]
[[Category: Graslund, S]]
[[Category: Hammarstrom M]]
[[Category: Hammarstrom, M]]
[[Category: Johansson A]]
[[Category: Johansson, A]]
[[Category: Johansson I]]
[[Category: Johansson, I]]
[[Category: Karlberg T]]
[[Category: Karlberg, T]]
[[Category: Kotenyova T]]
[[Category: Kotenyova, T]]
[[Category: Kotzsch A]]
[[Category: Kotzsch, A]]
[[Category: Moche M]]
[[Category: Moche, M]]
[[Category: Nielsen TK]]
[[Category: Nielsen, T K]]
[[Category: Nordlund P]]
[[Category: Nordlund, P]]
[[Category: Nyman T]]
[[Category: Nyman, T]]
[[Category: Persson C]]
[[Category: Persson, C]]
[[Category: Roos AK]]
[[Category: Roos, A K]]
[[Category: Sagemark J]]
[[Category: Structural genomic]]
[[Category: Schueler H]]
[[Category: Sagemark, J]]
[[Category: Schutz P]]
[[Category: Schueler, H]]
[[Category: Siponen MI]]
[[Category: Schutz, P]]
[[Category: Thorsell AG]]
[[Category: Siponen, M I]]
[[Category: Tresaugues L]]
[[Category: Thorsell, A G]]
[[Category: Van den Berg S]]
[[Category: Tresaugues, L]]
[[Category: Weigelt J]]
[[Category: Weigelt, J]]
[[Category: Welin M]]
[[Category: Welin, M]]
[[Category: Wisniewska M]]
[[Category: Wisniewska, M]]
[[Category: Atp-binding]]
[[Category: Chaperone]]
[[Category: Nucleotide-binding]]
[[Category: Phosphoprotein]]
[[Category: Protein-adp complex]]
[[Category: Sgc]]
[[Category: Stress response]]