Sandbox Reserved 1710: Difference between revisions
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== Introduction == | == Introduction == | ||
[[Image:Neurofibromin Surface w Labels.jpg|500 px|right|thumb|Figure 1: Surface Rendering of Neurofibromin in its Open and Closed Conformation.]] | [[Image:Neurofibromin Surface w Labels.jpg|500 px|right|thumb|Figure 1: Surface Rendering of Neurofibromin in its Open (7PGT) and Closed (7PGR) Conformation.]] | ||
Neurofibromin is encoded by [https://en.wikipedia.org/wiki/Neurofibromin_1 NF1 gene], located on chromosome 17. Neurofibromin functions as a tumor suppressor through its association with the protein [https://proteopedia.org/wiki/index.php/Ras Ras]. The molecular structure of Neurofibromin has been determined by [https://en.wikipedia.org/wiki/Cryogenic_electron_microscopy Cryo-Electron Microscopy]. The structure of neurofibromin isoform 2 revealed different functional states for the Neurofibromin protein.<ref name="Naschberger">PMID:34707296</ref> Mutations in Neurofibromin are associated with diseases such as [https://en.wikipedia.org/wiki/Neurofibroma Plexiform Neurofibromas]. (FLESH OUT INTRODUCTION) | Neurofibromin is encoded by [https://en.wikipedia.org/wiki/Neurofibromin_1 NF1 gene], located on chromosome 17. Neurofibromin functions as a tumor suppressor through its association with the protein [https://proteopedia.org/wiki/index.php/Ras Ras]. The molecular structure of Neurofibromin has been determined by [https://en.wikipedia.org/wiki/Cryogenic_electron_microscopy Cryo-Electron Microscopy]. The structure of neurofibromin isoform 2 revealed different functional states for the Neurofibromin protein.<ref name="Naschberger">PMID:34707296</ref> Mutations in Neurofibromin are associated with diseases such as [https://en.wikipedia.org/wiki/Neurofibroma Plexiform Neurofibromas]. (FLESH OUT INTRODUCTION) | ||
