Sandbox Reserved 1710: Difference between revisions
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== Structure == | == Structure == | ||
Neurofibromin is a <scene name='90/904315/Homodimer/5'>homodimer</scene> made up of two identical chains. Neurofibromin has two conformations, open and closed. Shifting between these controls neurofibromin's ability to associate with Ras and perform its function of Ras regulation. The transformation between the overall closed and open conformations transitions it from an active to inactive state. There are <scene name='90/904315/Sec14ph_and_grd_domain/1'>two important domains</scene> involved in the transition between the open and closed conformations, the <scene name='90/904316/Grd_domains/2'>GRD</scene> domain and the <scene name='90/904315/Sec14ph_domain/3'>Sec14-PH</scene> domain. Although neurofibromin is a homodimer with two identical protomers, only one protomer has its GRD and Sec14-PH domains rotated into the <scene name='90/904315/Open_conformation/4'>open conformation</scene>. | Neurofibromin is a <scene name='90/904315/Homodimer/5'>homodimer</scene> made up of two identical chains. Neurofibromin has two conformations, open and closed. Shifting between these controls neurofibromin's ability to associate with Ras and perform its function of Ras regulation. The transformation between the overall closed and open conformations transitions it from an active to inactive state. There are <scene name='90/904315/Sec14ph_and_grd_domain/1'>two important domains</scene> involved in the transition between the open and closed conformations, the <scene name='90/904316/Grd_domains/2'>GRD</scene> domain and the <scene name='90/904315/Sec14ph_domain/3'>Sec14-PH</scene> domain. The GRD and the Sec14-PH domain are centrally linked by an asymmetric, homodimeric core of four [https://en.wikipedia.org/wiki/Armadillo_repeat ARM] repeats and 27 [https://en.wikipedia.org/wiki/HEAT_repeat HEAT] repeats. The GRD and Sec14-PH domains extend out from the <scene name='90/904315/N-heat_arm/1'>N-HEAT/ARM</scene> core and then return to the <scene name='90/904315/C-heat_arm/1'>C-HEAT/ARM</scene> core. The orientation of the GRD and Sec-14 in relation to the N-HEAT/ARM and C-Heat/ARM determine what conformation neurofibromin is in. Although neurofibromin is a homodimer with two identical protomers, only one protomer has its GRD and Sec14-PH domains rotated into the <scene name='90/904315/Open_conformation/4'>open conformation</scene>. | ||
== Conformational States == | == Conformational States == | ||
