1gui: Difference between revisions

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[[Image:1gui.gif|left|200px]]
{{Seed}}
[[Image:1gui.png|left|200px]]


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{{STRUCTURE_1gui|  PDB=1gui  |  SCENE=  }}  
{{STRUCTURE_1gui|  PDB=1gui  |  SCENE=  }}  


'''CBM4 STRUCTURE AND FUNCTION'''
===CBM4 STRUCTURE AND FUNCTION===




==Overview==
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Enzymes active on complex carbohydrate polymers frequently have modular structures in which a catalytic domain is appended to one or more carbohydrate-binding modules (CBMs). Although CBMs have been classified into a number of families based upon sequence, many closely related CBMs are specific for different polysaccharides. In order to provide a structural rationale for the recognition of different polysaccharides by CBMs displaying a conserved fold, we have studied the thermodynamics of binding and three-dimensional structures of the related family 4 CBMs from Cellulomonas fimi Cel9B and Thermotoga maritima Lam16A in complex with their ligands, beta-1,4 and beta-1,3 linked gluco-oligosaccharides, respectively. These two CBMs use a structurally conserved constellation of aromatic and polar amino acid side-chains that interact with sugars in two of the five binding subsites. Differences in the length and conformation of loops in non-conserved regions create binding-site topographies that complement the known solution conformations of their respective ligands. Thermodynamics interpreted in the light of structural information highlights the differential role of water in the interaction of these CBMs with their respective oligosaccharide ligands.
The line below this paragraph, {{ABSTRACT_PUBMED_12079353}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 12079353 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12079353}}


==About this Structure==
==About this Structure==
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[[Category: Cellulose]]
[[Category: Cellulose]]
[[Category: Glucan]]
[[Category: Glucan]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:01:25 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 06:06:13 2008''

Revision as of 03:06, 1 July 2008

File:1gui.png

Template:STRUCTURE 1gui

CBM4 STRUCTURE AND FUNCTION

Template:ABSTRACT PUBMED 12079353

About this Structure

1GUI is a Single protein structure of sequence from Thermotoga maritima. Full crystallographic information is available from OCA.

Reference

Differential oligosaccharide recognition by evolutionarily-related beta-1,4 and beta-1,3 glucan-binding modules., Boraston AB, Nurizzo D, Notenboom V, Ducros V, Rose DR, Kilburn DG, Davies GJ, J Mol Biol. 2002 Jun 21;319(5):1143-56. PMID:12079353

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