1gux: Difference between revisions

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[[Image:1gux.gif|left|200px]]
{{Seed}}
[[Image:1gux.png|left|200px]]


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{{STRUCTURE_1gux|  PDB=1gux  |  SCENE=  }}  
{{STRUCTURE_1gux|  PDB=1gux  |  SCENE=  }}  


'''RB POCKET BOUND TO E7 LXCXE MOTIF'''
===RB POCKET BOUND TO E7 LXCXE MOTIF===




==Overview==
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The pocket domain of the retinoblastoma (Rb) tumour suppressor is central to Rb function, and is frequently inactivated by the binding of the human papilloma virus E7 oncoprotein in cervical cancer. The crystal structure of the Rb pocket bound to a nine-residue E7 peptide containing the LxCxE motif, shared by other Rb-binding viral and cellular proteins, shows that the LxCxE peptide binds a highly conserved groove on the B-box portion of the pocket; the A-box portion appears to be required for the stable folding of the B box. Also highly conserved is the extensive A-B interface, suggesting that it may be an additional protein-binding site. The A and B boxes each contain the cyclin-fold structural motif, with the LxCxE-binding site on the B-box cyclin fold being similar to a Cdk2-binding site of cyclin A and to a TBP-binding site of TFIIB.
The line below this paragraph, {{ABSTRACT_PUBMED_9495340}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 9495340 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9495340}}


==About this Structure==
==About this Structure==
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[[Category: Retinoblastoma]]
[[Category: Retinoblastoma]]
[[Category: Tumor suppressor protein]]
[[Category: Tumor suppressor protein]]
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