2xak: Difference between revisions

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<StructureSection load='2xak' size='340' side='right'caption='[[2xak]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
<StructureSection load='2xak' size='340' side='right'caption='[[2xak]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2xak]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Ecoli Ecoli]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2x0z 2x0z]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XAK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XAK FirstGlance]. <br>
<table><tr><td colspan='2'>[[2xak]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2x0z 2x0z]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XAK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XAK FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NIY:META-NITRO-TYROSINE'>NIY</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1rsr|1rsr]], [[1mxr|1mxr]], [[3r1r|3r1r]], [[1pim|1pim]], [[1jqc|1jqc]], [[2r1r|2r1r]], [[4r1r|4r1r]], [[1piy|1piy]], [[1biq|1biq]], [[1rlr|1rlr]], [[1r65|1r65]], [[2alx|2alx]], [[1r1r|1r1r]], [[1av8|1av8]], [[1xik|1xik]], [[7r1r|7r1r]], [[2av8|2av8]], [[1rnr|1rnr]], [[1qfn|1qfn]], [[1mrr|1mrr]], [[1rib|1rib]], [[1jpr|1jpr]], [[5r1r|5r1r]], [[1pj1|1pj1]], [[1pfr|1pfr]], [[6r1r|6r1r]], [[1pj0|1pj0]], [[1rsv|1rsv]], [[1piu|1piu]], [[1yfd|1yfd]], [[2x0x|2x0x]], [[1piz|1piz]], [[1pm2|1pm2]], [[2xap|2xap]], [[2xaz|2xaz]], [[2xav|2xav]], [[2xax|2xax]], [[2xay|2xay]], [[2xaw|2xaw]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NIY:META-NITRO-TYROSINE'>NIY</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Ribonucleoside-diphosphate_reductase Ribonucleoside-diphosphate reductase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.4.1 1.17.4.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xak FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xak OCA], [https://pdbe.org/2xak PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xak RCSB], [https://www.ebi.ac.uk/pdbsum/2xak PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xak ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xak FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xak OCA], [https://pdbe.org/2xak PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xak RCSB], [https://www.ebi.ac.uk/pdbsum/2xak PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xak ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/RIR1_ECOLI RIR1_ECOLI]] Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R1 contains the binding sites for both substrates and allosteric effectors and carries out the actual reduction of the ribonucleotide. It also provides redox-active cysteines. [[https://www.uniprot.org/uniprot/RIR2_ECOLI RIR2_ECOLI]] Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R2 contains the tyrosyl radical required for catalysis.  
[https://www.uniprot.org/uniprot/RIR1_ECOLI RIR1_ECOLI] Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R1 contains the binding sites for both substrates and allosteric effectors and carries out the actual reduction of the ribonucleotide. It also provides redox-active cysteines.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Ecoli]]
[[Category: Escherichia coli K-12]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Ribonucleoside-diphosphate reductase]]
[[Category: Stubbe J]]
[[Category: Stubbe, J]]
[[Category: Uhlin U]]
[[Category: Uhlin, U]]
[[Category: Yokoyama K]]
[[Category: Yokoyama, K]]
[[Category: Allosteric enzyme]]
[[Category: Dna replication]]
[[Category: Nucleotide-binding]]
[[Category: Oxidoreductase]]
Retrieved from "https://proteopedia.org/2xak"