3i3c: Difference between revisions
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<StructureSection load='3i3c' size='340' side='right'caption='[[3i3c]], [[Resolution|resolution]] 2.48Å' scene=''> | <StructureSection load='3i3c' size='340' side='right'caption='[[3i3c]], [[Resolution|resolution]] 2.48Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3i3c]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[3i3c]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I3C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3I3C FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.48Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3i3c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i3c OCA], [https://pdbe.org/3i3c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3i3c RCSB], [https://www.ebi.ac.uk/pdbsum/3i3c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3i3c ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3i3c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i3c OCA], [https://pdbe.org/3i3c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3i3c RCSB], [https://www.ebi.ac.uk/pdbsum/3i3c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3i3c ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/CBX5_HUMAN CBX5_HUMAN] Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.<ref>PMID:19783980</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Amaya | [[Category: Amaya MF]] | ||
[[Category: Arrowsmith | [[Category: Arrowsmith CH]] | ||
[[Category: Bochkarev | [[Category: Bochkarev A]] | ||
[[Category: Bountra | [[Category: Bountra C]] | ||
[[Category: Edwards | [[Category: Edwards AM]] | ||
[[Category: Kozieradzki | [[Category: Kozieradzki I]] | ||
[[Category: Li | [[Category: Li Y]] | ||
[[Category: Li | [[Category: Li Z]] | ||
[[Category: Min | [[Category: Min J]] | ||
[[Category: Ouyang | [[Category: Ouyang H]] | ||
[[Category: Weigelt J]] | |||
[[Category: Weigelt | |||
Latest revision as of 10:03, 21 February 2024
Crystal Structural of CBX5 Chromo Shadow Domain
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