3i87: Difference between revisions

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<StructureSection load='3i87' size='340' side='right'caption='[[3i87]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='3i87' size='340' side='right'caption='[[3i87]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3i87]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I87 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3I87 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3i87]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I87 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3I87 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3i6p|3i6p]], [[3i71|3i71]], [[3i82|3i82]], [[3i96|3i96]], [[3ia0|3ia0]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">b2439, eutL, JW2432, yffJ ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3i87 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i87 OCA], [https://pdbe.org/3i87 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3i87 RCSB], [https://www.ebi.ac.uk/pdbsum/3i87 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3i87 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3i87 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i87 OCA], [https://pdbe.org/3i87 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3i87 RCSB], [https://www.ebi.ac.uk/pdbsum/3i87 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3i87 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/EUTL_ECOLI EUTL_ECOLI]] May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place.  
[https://www.uniprot.org/uniprot/EUTL_ECOLI EUTL_ECOLI] May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3i87 ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3i87 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Many bacterial cells contain proteinaceous microcompartments that act as simple organelles by sequestering specific metabolic processes involving volatile or toxic metabolites. Here we report the three-dimensional (3D) crystal structures, with resolutions between 1.65 and 2.5 angstroms, of the four homologous proteins (EutS, EutL, EutK, and EutM) that are thought to be the major shell constituents of a functionally complex ethanolamine utilization (Eut) microcompartment. The Eut microcompartment is used to sequester the metabolism of ethanolamine in bacteria such as Escherichia coli and Salmonella enterica. The four Eut shell proteins share an overall similar 3D fold, but they have distinguishing structural features that help explain the specific roles they play in the microcompartment. For example, EutL undergoes a conformational change that is probably involved in gating molecular transport through shell protein pores, whereas structural evidence suggests that EutK might bind a nucleic acid component. Together these structures give mechanistic insight into bacterial microcompartments.
Structure and mechanisms of a protein-based organelle in Escherichia coli.,Tanaka S, Sawaya MR, Yeates TO Science. 2010 Jan 1;327(5961):81-4. PMID:20044574<ref>PMID:20044574</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3i87" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Ecoli]]
[[Category: Escherichia coli K-12]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Sawaya, M R]]
[[Category: Sawaya MR]]
[[Category: Tanaka, S]]
[[Category: Tanaka S]]
[[Category: Yeates, T O]]
[[Category: Yeates TO]]
[[Category: Structural protein]]

Latest revision as of 10:04, 21 February 2024

Ethanolamine Utilization Microcompartment Shell Subunit, EutL Open Form

3i87, resolution 2.30Å

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