Sandbox Reserved 1724: Difference between revisions
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VKOR uses two catalytic amino acids, <scene name='90/904329/Kohhbond/3'>tyrosine 139 and asparagine 80</scene> to stabilize vitamin K in the binding pocket. Tyr139 and Asn80 hydrogen bond to carbonyl groups on both structures and stabilizes them within the binding pocket <ref name="Liu">PMID:33154105</ref>. | VKOR uses two catalytic amino acids, <scene name='90/904329/Kohhbond/3'>tyrosine 139 and asparagine 80</scene> to stabilize vitamin K in the binding pocket. Tyr139 and Asn80 hydrogen bond to carbonyl groups on both structures and stabilizes them within the binding pocket <ref name="Liu">PMID:33154105</ref>. | ||
Other than the two previously mentioned hydrogen bonds (Tyr139 and Asn80), | Other than the two previously mentioned hydrogen bonds (Tyr139 and Asn80), vitamin K is also bound via hydrophobic interactions within the binding pocket of VKOR. Hydrophobic residues of VKOR such as <scene name='90/904329/Kohydroaa/4'>Phe83, Phe87, Tyr88</scene>, form a hydrophobic tunnel within the binding pocket <ref name="Liu">PMID:33154105</ref>. | ||
== Catalytic Cycle == | == Catalytic Cycle == | ||
