Sandbox Reserved 1706: Difference between revisions

==Introduction==

[https://en.wikipedia.org/wiki/Neurofibromatosis_type_I Neurofibromatosis Type 1] is a genetic disorder caused by mutations in the tumor suppressor gene NF1 that codes for the [https://en.wikipedia.org/wiki/GTPase-activating_protein GTPase-activating protein] neurofibromin. Neurofibromin is closely involved in signaling pathways such as [https://en.wikipedia.org/wiki/MAPK/ERK_pathway MAPK/ERK], [https://en.wikipedia.org/wiki/PI3K/AKT/mTOR_pathway P13K/AKT/mTOR], and other cell signaling pathways that use [https://en.wikipedia.org/wiki/Ras_GTPase Ras] <ref name="Bergoug"> DOI:10.3390/cells9112365</ref>. Mutations that cause a decrease in activity of neurofibromin cause tumors to grow along your nerves. As neurofibromin is ubiquitously expressed throughout the body, these tumors can grow anywhere. Neurofibromin is located in the [https://en.wikipedia.org/wiki/Cytosol cytosol] of the cell but is recruited to the [https://en.wikipedia.org/wiki/Cell_membrane plasma membrane] to bind to [https://en.wikipedia.org/wiki/Ras_GTPase Ras]. The structure of neurofibromin was detemed through high-resolution single particles [https://en.wikipedia.org/wiki/Cryogenic_electron_microscopy cryogenic electron microscopy] to understand the overall structure and the different domains. [https://en.wikipedia.org/wiki/X-ray_crystallography#:~:text=X%2Dray%20crystallography%20is%20the,diffract%20into%20many%20specific%20directions. X-Ray crystallography] experiments found inconsistency in the structural determination.<ref name="Bergoug"> DOI:10.3390/cells9112365</ref><ref name="Bourne"> DOI:10.1038/39470</ref><ref name="Lupton"> DOI:10.1038/s41594-021-00687-2</ref><ref name="Naschberger"> DOI:10.1038/s41586-021-04024-x</ref>   

==Function==