Sandbox Reserved 1706: Difference between revisions
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<StructureSection load='7PGR' size='350' frame='true' | <StructureSection load='7PGR' size='350' frame='true' | ||
side='right' caption='Neurofibromin | side='right' caption='Neurofibromin Open Conformation PDB code:[https://www.rcsb.org/structure/7PGT 7PGT]' scene='90/904311/Open_conformation/9'> | ||
[[Image:Open_photo.png|700px|right|thumb]] | [[Image:Open_photo.png|700px|right|thumb]] | ||
==Introduction== | ==Introduction== | ||
[https://en.wikipedia.org/wiki/Neurofibromatosis_type_I Neurofibromatosis Type 1] is a genetic disorder caused by mutations in the tumor suppressor gene NF1 that codes for the [https://en.wikipedia.org/wiki/GTPase-activating_protein GTPase-activating protein] neurofibromin. Neurofibromin is closely involved in signaling pathways such as [https://en.wikipedia.org/wiki/MAPK/ERK_pathway MAPK/ERK], [https://en.wikipedia.org/wiki/PI3K/AKT/mTOR_pathway P13K/AKT/mTOR], and other cell signaling pathways that use [https://en.wikipedia.org/wiki/Ras_GTPase Ras] <ref name="Bergoug"> DOI:10.3390/cells9112365</ref>. Mutations that cause a decrease in activity of neurofibromin cause tumors to grow along your nerves. As neurofibromin is ubiquitously expressed throughout the body, these tumors can grow anywhere. Neurofibromin is located in the [https://en.wikipedia.org/wiki/Cytosol cytosol] of the cell but is recruited to the [https://en.wikipedia.org/wiki/Cell_membrane plasma membrane] to bind to [https://en.wikipedia.org/wiki/Ras_GTPase Ras]. The structure of neurofibromin was detemed through high-resolution single particles [https://en.wikipedia.org/wiki/Cryogenic_electron_microscopy cryogenic electron microscopy] to understand the overall structure and the different domains. [https://en.wikipedia.org/wiki/X-ray_crystallography#:~:text=X%2Dray%20crystallography%20is%20the,diffract%20into%20many%20specific%20directions. X-Ray crystallography] experiments found inconsistency in the structural determination.<ref name="Bergoug"> DOI:10.3390/cells9112365</ref><ref name="Bourne"> DOI:10.1038/39470</ref><ref name="Lupton"> DOI:10.1038/s41594-021-00687-2</ref><ref name="Naschberger"> DOI:10.1038/s41586-021-04024-x</ref> | [https://en.wikipedia.org/wiki/Neurofibromatosis_type_I Neurofibromatosis Type 1] is a genetic disorder caused by mutations in the tumor suppressor gene NF1 that codes for the [https://en.wikipedia.org/wiki/GTPase-activating_protein GTPase-activating protein] neurofibromin. Neurofibromin is closely involved in signaling pathways such as [https://en.wikipedia.org/wiki/MAPK/ERK_pathway MAPK/ERK], [https://en.wikipedia.org/wiki/PI3K/AKT/mTOR_pathway P13K/AKT/mTOR], and other cell signaling pathways that use [https://en.wikipedia.org/wiki/Ras_GTPase Ras] <ref name="Bergoug"> DOI:10.3390/cells9112365</ref>. Mutations that cause a decrease in activity of neurofibromin cause tumors to grow along your nerves. As neurofibromin is ubiquitously expressed throughout the body, these tumors can grow anywhere. Neurofibromin is located in the [https://en.wikipedia.org/wiki/Cytosol cytosol] of the cell but is recruited to the [https://en.wikipedia.org/wiki/Cell_membrane plasma membrane] to bind to [https://en.wikipedia.org/wiki/Ras_GTPase Ras]. The structure of neurofibromin was detemed through high-resolution single particles [https://en.wikipedia.org/wiki/Cryogenic_electron_microscopy cryogenic electron microscopy] to understand the overall structure and the different domains. [https://en.wikipedia.org/wiki/X-ray_crystallography#:~:text=X%2Dray%20crystallography%20is%20the,diffract%20into%20many%20specific%20directions. X-Ray crystallography] experiments found inconsistency in the structural determination.<ref name="Bergoug"> DOI:10.3390/cells9112365</ref><ref name="Bourne"> DOI:10.1038/39470</ref><ref name="Lupton"> DOI:10.1038/s41594-021-00687-2</ref><ref name="Naschberger"> DOI:10.1038/s41586-021-04024-x</ref> | ||
==Function== | ==Function== | ||
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==FINAL SCENES COPY AND PASTE== | ==FINAL SCENES COPY AND PASTE== | ||
Domain Scenes- | Domain Scenes- | ||
<scene name='90/904311/Domainintro_open/ | <scene name='90/904311/Domainintro_open/6'>Domain Intro</scene> | ||
<scene name='90/904311/N-heatarm_open/ | <scene name='90/904311/N-heatarm_open/2'>N-HEATARM</scene> | ||
<scene name='90/904311/C-heatarm_open/ | <scene name='90/904311/C-heatarm_open/2'>C-HEATARM</scene> | ||
<scene name='90/904311/Grd_open/ | <scene name='90/904311/Grd_open/2'>GRD Open</scene> | ||
<scene name='90/904311/Gapex_open/ | <scene name='90/904311/Gapex_open/2'>GAPex Open</scene> | ||
<scene name='90/904311/Sec14ph_open/ | <scene name='90/904311/Sec14ph_open/2'>Sec14PH Open</scene> | ||
==References placeholders== | ==References placeholders== | ||
