Sandbox Reserved 1709: Difference between revisions

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	=== Mutations ===		=== Mutations ===
	Within the <scene name='90/904314/Active_site/2'>binding pocket</scene> mutations of the <scene name='90/904314/Vkor_with_warfarin_bound/4'>active site residues</scene> can occur. These mutations can be detrimental to the VKOR structure and function<ref>DOI 10.~~101126~~</ref>. Two of the most common mutations occur to residues N80 and Y139 mutating them to <scene name='90/904314/Active_site_mutations/2'>A80 and F139</scene>. The change in polarity of these mutations from polar to nonpolar will cause a decrease in recognition and stabilization due to the inability to provide hydrogen bonds.		Within the <scene name='90/904314/Active_site/2'>binding pocket</scene> mutations of the <scene name='90/904314/Vkor_with_warfarin_bound/4'>active site residues</scene> can occur. These mutations can be detrimental to the VKOR structure and function<ref>DOI 10.1126</ref>. Two of the most common mutations occur to residues N80 and Y139 mutating them to <scene name='90/904314/Active_site_mutations/2'>A80 and F139</scene>. The change in polarity of these mutations from polar to nonpolar will cause a decrease in recognition and stabilization due to the inability to provide hydrogen bonds.

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