Sandbox Reserved 1719: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 105: | Line 105: | ||
=== Disulfide bonds === | === Disulfide bonds === | ||
In general, class A GPCRs have a <scene name='90/904324/5ht2a/4'>conserved disulfide bond</scene> between TM3 and ECL2.<ref name="Can"/> In contrast, the MRGPRX2 <scene name='90/904324/Mrgprx2_disulfide_bonds/5'>disulfide bond</scene> | In general, class A GPCRs have a <scene name='90/904324/5ht2a/4'>conserved disulfide bond</scene> between TM3 and ECL2.<ref name="Can"/> In contrast, '''Figure 8''' shows the location MRGPRX2 <scene name='90/904324/Mrgprx2_disulfide_bonds/5'>disulfide bond</scene> between Cys168 of TM4 and Cys180 of TM5, which structurally flips ECL2 to the top of TM4 and TM5.<ref name="Can"/> This creates the wide ligand-binding surface of MRGPRX2 that contributes to surface level binding which allows diverse ligand interactions.<ref name="Can"/> | ||
[[Image:Disulfide_bond_comparison.png|500px|center|thumb|'''Figure 8.''' Comparison of disulfide bond location in MRGPRX2 (blue) and 5HT2AR (purple).]] | [[Image:Disulfide_bond_comparison.png|500px|center|thumb|'''Figure 8.''' Comparison of disulfide bond location in MRGPRX2 (blue) and 5HT2AR (purple).]] | ||
