Sandbox Reserved 1719: Difference between revisions
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== Related Enzymes == | == Related Enzymes == | ||
Among Human Itch GPCRs, MRGPRX2 is a class A GPCR that regulates mast cell degranulation and itch-related hypersensitivity reactions.<ref name="Can">DOI: 10.1038/s41586-021-04126-6</ref><ref name="Yang"/> MRGPRX2 is also a target of morphinan alkaloids, like morphine, codeine, and dextromethorphan.<ref name="Can"/><ref name="Yang"/> MRGPRX2 couples to nearly all G-protein families and subtypes with robust coupling to G<sub>q</sub> and G<sub>i</sub> families.<ref name="Can"/><ref name="Yang"/> | Among Human Itch GPCRs, <scene name='90/904324/Mrgprx2/5'>MRGPRX2</scene> is a class A GPCR that regulates mast cell degranulation and itch-related hypersensitivity reactions.<ref name="Can">DOI: 10.1038/s41586-021-04126-6</ref><ref name="Yang"/> MRGPRX2 is also a target of morphinan alkaloids, like morphine, codeine, and dextromethorphan.<ref name="Can"/><ref name="Yang"/> MRGPRX2 couples to nearly all G-protein families and subtypes with robust coupling to G<sub>q</sub> and G<sub>i</sub> families.<ref name="Can"/><ref name="Yang"/> | ||
<scene name='90/904324/7s8p_mx4/4'>MRGPRX4</scene> is another sub-group of the MRGPRX family, which mediates cholestatic itch and is a target of nateglinide drugs.<ref name="Can"/><ref name="Yang"/> MRGPRX4 also couples to G<sub>q</sub> and G<sub>i</sub> similar to MRGPRX2. | <scene name='90/904324/7s8p_mx4/4'>MRGPRX4</scene> is another sub-group of the MRGPRX family, which mediates cholestatic itch and is a target of nateglinide drugs.<ref name="Can"/><ref name="Yang"/> MRGPRX4 also couples to G<sub>q</sub> and G<sub>i</sub> similar to MRGPRX2. | ||
