Sandbox Reserved 1700: Difference between revisions
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==== Disulfide Bonds ==== | ==== Disulfide Bonds ==== | ||
The MRGPRX2 disulfide bond is between <scene name='90/904305/Disulfide_bond/ | The MRGPRX2 disulfide bond is between <scene name='90/904305/Disulfide_bond/2'>Cys-168 and Cys-180</scene> on TM helices 5 and 4, respectively. In other class A GPCRs, this disulfide bond is between and extracellular loop (ECL2) and a TM helix (TM3). For example, the <scene name='90/904306/5ht2a_disulfide/2'>serotonin GPCR</scene> shows this disulfide bond between the ECL2 and TM3. This different disulfide bond location contributes to surface level binding of ligands. | ||
[[Image:Screen Shot 2022-03-27 at 5.45.52 PM.png|300px|center|thumb|'''Figure 5.''' Overlay of the 5HT2AR and MRGPRX2 TMP for comparison of disulfide bond location.]] | [[Image:Screen Shot 2022-03-27 at 5.45.52 PM.png|300px|center|thumb|'''Figure 5.''' Overlay of the 5HT2AR and MRGPRX2 TMP for comparison of disulfide bond location.]] | ||
