Sandbox Reserved 1719: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
No edit summary
No edit summary
Line 83: Line 83:


=== Sodium binding site ===
=== Sodium binding site ===
The [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4106411/ sodium binding site] conserved in class A GPCRs allosterically modulates the stabilization of the GPCR's inactive state. The <scene name='90/904324/Mrgprx2_sodium_site/3'>sodium binding site</scene> of MRGPRX2 contains the conserved Asp75, however, the conserved Ser116 on TM3 seen in class A GPCRs is replaced by Gly116.<ref name="Can"/> The presence of Gly as opposed to the polar Ser contributes to a lack of polar character in addition to decreasing the size of the binding pocket. Both factors thereby limit the binding of sodium ions to the [https://proteopedia.org/wiki/index.php/Neurotensin_receptor#sodium%20binding%20pocket sodium binding site] in MRGPRX2.<ref name="Can"/>
The [https://proteopedia.org/wiki/index.php/Neurotensin_receptor#sodium%20binding%20pocket sodium binding site] conserved in class A GPCRs allosterically modulates the stabilization of the GPCR's inactive state. The <scene name='90/904324/Mrgprx2_sodium_site/3'>sodium binding site</scene> of MRGPRX2 contains the conserved Asp75, however, the conserved Ser116 on TM3 seen in class A GPCRs is replaced by Gly116.<ref name="Can"/> The presence of Gly as opposed to the polar Ser contributes to a lack of polar character in addition to decreasing the size of the binding pocket. Both factors thereby limit the binding of sodium ions to the sodium binding site in MRGPRX2.<ref name="Can"/>


= Mechanism =
= Mechanism =
Retrieved from "https://proteopedia.org/Sandbox_Reserved_1719"