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| [[Image:1gwk.jpg|left|200px]] | | {{Seed}} |
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| {{STRUCTURE_1gwk| PDB=1gwk | SCENE= }} | | {{STRUCTURE_1gwk| PDB=1gwk | SCENE= }} |
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| '''CARBOHYDRATE BINDING MODULE FAMILY29'''
| | ===CARBOHYDRATE BINDING MODULE FAMILY29=== |
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| ==Overview==
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| Carbohydrate-protein recognition is central to many biological processes. Enzymes that act on polysaccharide substrates frequently contain noncatalytic domains, "carbohydrate-binding modules" (CBMs), that target the enzyme to the appropriate substrate. CBMs that recognize specific plant structural polysaccharides are often able to accommodate both the variable backbone and the side-chain decorations of heterogeneous ligands. "CBM29" modules, derived from a noncatalytic component of the Piromyces equi cellulase/hemicellulase complex, provide an example of this selective yet flexible recognition. They discriminate strongly against some polysaccharides while remaining relatively promiscuous toward both beta-1,4-linked manno- and cello-oligosaccharides. This feature may reflect preferential, but flexible, targeting toward glucomannans in the plant cell wall. The three-dimensional structure of CBM29-2 and its complexes with cello- and mannohexaose reveal a beta-jelly-roll topology, with an extended binding groove on the concave surface. The orientation of the aromatic residues complements the conformation of the target sugar polymer while accommodation of both manno- and gluco-configured oligo- and polysaccharides is conferred by virtue of the plasticity of the direct interactions from their axial and equatorial 2-hydroxyls, respectively. Such flexible ligand recognition targets the anaerobic fungal complex to a range of different components in the plant cell wall and thus plays a pivotal role in the highly efficient degradation of this composite structure by the microbial eukaryote.
| | The line below this paragraph, {{ABSTRACT_PUBMED_12391332}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 12391332 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_12391332}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Glucomannan]] | | [[Category: Glucomannan]] |
| [[Category: Mannohexaose]] | | [[Category: Mannohexaose]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:06:10 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 06:13:19 2008'' |
