Sandbox Reserved 1716: Difference between revisions

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===Step IV===

<scene name='90/904321/Iv/1'>Step IV</scene> is the last step of this cycle. A bond between Cys43 and Cys51 causes an electron transfer to Cys132. In its reduced form Cys132 will attack Cys135, and the extra electrons are kicked to Vitamin K Epoxide. This opens the epoxide ring on Vitamin K Epoxide so that it may be reformed into Vitamin K Quinone. Vitamin K Quinone is released from Vitamin K Epoxide Reductase. ~~This is step <scene name='90/904321/Iv/1'>IV</scene>, which~~ is a fully oxidized open conformation ~~of VKOR~~. This process is repeated over and over unless interrupted by inhibitors known as Vitamin K Antagonists or VKAs. Vitamin K Quinone will exit the central binding pocket and the open conformation will form. VKOR is in its fully oxidized state after donating its electrons to Vitamin K Epoxide. This is when the luminal helix will be visible. The cycle then repeats at Step I to keep reducing Vitamin K Epoxide to Vitamin K Quinone. <ref name="Liu"/>

<scene name='90/904321/Iv/1'>Step IV</scene> is the last step of this cycle. A bond between Cys43 and Cys51 causes an electron transfer to Cys132. In its reduced form Cys132 will attack Cys135, and the extra electrons are kicked to Vitamin K Epoxide. This opens the epoxide ring on Vitamin K Epoxide so that it may be reformed into Vitamin K Quinone. Vitamin K Quinone is released from Vitamin K Epoxide Reductase. VKOR is in a fully oxidized open conformation. This process is repeated over and over unless interrupted by inhibitors known as Vitamin K Antagonists or VKAs. Vitamin K Quinone will exit the central binding pocket and the open conformation will form. VKOR is in its fully oxidized state after donating its electrons to Vitamin K Epoxide. This is when the luminal helix will be visible. The cycle then repeats at Step I to keep reducing Vitamin K Epoxide to Vitamin K Quinone. <ref name="Liu"/>

Sandbox Reserved 1716: Difference between revisions

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Revision as of 16:03, 19 April 2022 view source Kiana Jackson (talk \| contribs) 153 edits No edit summary ← Older edit		Revision as of 16:06, 19 April 2022 view source Kiana Jackson (talk \| contribs) 153 edits No edit summary Newer edit →
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	===Step IV===		===Step IV===
	<scene name='90/904321/Iv/1'>Step IV</scene> is the last step of this cycle. A bond between Cys43 and Cys51 causes an electron transfer to Cys132. In its reduced form Cys132 will attack Cys135, and the extra electrons are kicked to Vitamin K Epoxide. This opens the epoxide ring on Vitamin K Epoxide so that it may be reformed into Vitamin K Quinone. Vitamin K Quinone is released from Vitamin K Epoxide Reductase. ~~This is step <scene name='90/904321/Iv/1'>IV</scene>, which~~ is a fully oxidized open conformation ~~of VKOR~~. This process is repeated over and over unless interrupted by inhibitors known as Vitamin K Antagonists or VKAs. Vitamin K Quinone will exit the central binding pocket and the open conformation will form. VKOR is in its fully oxidized state after donating its electrons to Vitamin K Epoxide. This is when the luminal helix will be visible. The cycle then repeats at Step I to keep reducing Vitamin K Epoxide to Vitamin K Quinone. <ref name="Liu"/>		<scene name='90/904321/Iv/1'>Step IV</scene> is the last step of this cycle. A bond between Cys43 and Cys51 causes an electron transfer to Cys132. In its reduced form Cys132 will attack Cys135, and the extra electrons are kicked to Vitamin K Epoxide. This opens the epoxide ring on Vitamin K Epoxide so that it may be reformed into Vitamin K Quinone. Vitamin K Quinone is released from Vitamin K Epoxide Reductase. VKOR is in a fully oxidized open conformation. This process is repeated over and over unless interrupted by inhibitors known as Vitamin K Antagonists or VKAs. Vitamin K Quinone will exit the central binding pocket and the open conformation will form. VKOR is in its fully oxidized state after donating its electrons to Vitamin K Epoxide. This is when the luminal helix will be visible. The cycle then repeats at Step I to keep reducing Vitamin K Epoxide to Vitamin K Quinone. <ref name="Liu"/>