Sandbox Reserved 1723: Difference between revisions

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== Clinical Relevance ==
== Clinical Relevance ==


[[Image:Drugs_and_zinc.PNG|450px|right|thumb|'''Figure 6''': Structures of (R)-Zinc-3573, Dextromethorphan, Morphine, and Codeine. The red circles indicate conserved basic N-dimethyl group and the blue squares show the conserved benzene rings.<ref name="Cao"/>]]
[[Image:Zinc_and_drugs_snip.PNG|450px|right|thumb|'''Figure 6''': Structures of (R)-Zinc-3573, Dextromethorphan, Morphine, and Codeine. The blue circles indicate conserved basic N-dimethyl group and the green squares show the conserved benzene rings.<ref name="Cao"/>]]


MRGPRX2 activation is associated with chronic itching or anaphylaxis reactions, a common side effect of many prescribed medications. <ref name="Cao"/> Among these drugs are opiods [https://en.wikipedia.org/wiki/Morphine morphine] and [https://en.wikipedia.org/wiki/Codeine codeine] and [https://en.wikipedia.org/wiki/Dextromethorphan dextromethorphan]. By analyzing the structures of these drugs, it can be seen that they contain chemical features similar to agonist R-Zinc-3573 (see Figure 4). They contain a conserved benzene ring that stabilizes them in binding pocket one (See Figure 3). Similarly, they contain an N-dimethyl group that would allow them to form key bonds with residues Asp-184 and Glu-164. Lastly, these drugs have a similar shape and size to that of the agonist R-Zinc-3573.<ref name="Babina"> Babina, M., et al. "MRGPRX2 Is the Codeine Receptor of Human Skin Mast Cells: Desensitization through β-Arrestin and Lack of Correlation with the FcεRI Pathway." Journal of Investigative Dermatology, 141(6), 1286-1296. https://doi.org/10.1016/j.jid.2020.09.017</ref> These structural and chemical similarities indicate the possibility of a similar binding mechanism.  
MRGPRX2 activation is associated with chronic itching or anaphylaxis reactions, a common side effect of many prescribed medications. <ref name="Cao"/> Among these drugs are opiods [https://en.wikipedia.org/wiki/Morphine morphine] and [https://en.wikipedia.org/wiki/Codeine codeine] and [https://en.wikipedia.org/wiki/Dextromethorphan dextromethorphan]. By analyzing the structures of these drugs, it can be seen that they contain chemical features similar to agonist R-Zinc-3573 (see Figure 4). They contain a conserved benzene ring that stabilizes them in binding pocket one (See Figure 3). Similarly, they contain an N-dimethyl group that would allow them to form key bonds with residues Asp-184 and Glu-164. Lastly, these drugs have a similar shape and size to that of the agonist R-Zinc-3573.<ref name="Babina"> Babina, M., et al. "MRGPRX2 Is the Codeine Receptor of Human Skin Mast Cells: Desensitization through β-Arrestin and Lack of Correlation with the FcεRI Pathway." Journal of Investigative Dermatology, 141(6), 1286-1296. https://doi.org/10.1016/j.jid.2020.09.017</ref> These structural and chemical similarities indicate the possibility of a similar binding mechanism.  
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