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== G-Protein Coupled Receptors ==

[https://proteopedia.org/wiki/index.php/G_protein-coupled_receptors G-protein coupled receptors](GCPRs) are a large family of cell surface membrane receptors. Once bound to a wide variety of extracellular ligands, GCPRs undergo a conformational change and relay information to intracellular secondary messengers <ref name="Thal">Thal, David M., et al. "Structural insights into G-protein-coupled receptor allostery." Nature, Nature Publishing Group, 04 July 2018, https://www.nature.com/articles/s41586-018-0259-z</ref>. This G protein activation results in a cellular response dependent on the ligand bound and location of the GPCR in the body. GCPRs can be broken down into five families: the [https://en.wikipedia.org/wiki/Rhodopsin-like_receptors rhodopsin family (class A)], the [https://en.wikipedia.org/wiki/Secretin_receptor_family secretin family (class B)], the [https://en.wikipedia.org/wiki/Adhesion_G_protein-coupled_receptor adhesion family], the [https://en.wikipedia.org/wiki/Class_C_GPCR glutamate family (class C)], and the [https://en.wikipedia.org/wiki/Frizzled frizzled/taste family (class F)] <ref name="Zhang">PMID: 26467290</ref>. All of the families have a similar transmembrane (TM) domain consisting of ~~seven~~ <scene name='90/904328/7tm_domain_pt_3/7'> 7 α-helices</scene> complexed with intracellular G proteins (Figure 1).

[https://proteopedia.org/wiki/index.php/G_protein-coupled_receptors G-protein coupled receptors](GCPRs) are a large family of cell surface membrane receptors. Once bound to a wide variety of extracellular ligands, GCPRs undergo a conformational change and relay information to intracellular secondary messengers <ref name="Thal">Thal, David M., et al. "Structural insights into G-protein-coupled receptor allostery." Nature, Nature Publishing Group, 04 July 2018, https://www.nature.com/articles/s41586-018-0259-z</ref>. This G protein activation results in a cellular response dependent on the ligand bound and location of the GPCR in the body. GCPRs can be broken down into five families: the [https://en.wikipedia.org/wiki/Rhodopsin-like_receptors rhodopsin family (class A)], the [https://en.wikipedia.org/wiki/Secretin_receptor_family secretin family (class B)], the [https://en.wikipedia.org/wiki/Adhesion_G_protein-coupled_receptor adhesion family], the [https://en.wikipedia.org/wiki/Class_C_GPCR glutamate family (class C)], and the [https://en.wikipedia.org/wiki/Frizzled frizzled/taste family (class F)] <ref name="Zhang">PMID: 26467290</ref>. All of the families have a similar transmembrane (TM) domain consisting of <scene name='90/904328/7tm_domain_pt_3/7'>seven α-helices</scene> complexed with intracellular G proteins (Figure 1).

=== Class A GCPRs ===

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 == G-Protein Coupled Receptors ==
-[https://proteopedia.org/wiki/index.php/G_protein-coupled_receptors G-protein coupled receptors](GCPRs) are a large family of cell surface membrane receptors. Once bound to a wide variety of extracellular ligands, GCPRs undergo a conformational change and relay information to intracellular secondary messengers <ref name="Thal">Thal, David M., et al. "Structural insights into G-protein-coupled receptor allostery." Nature, Nature Publishing Group, 04 July 2018, https://www.nature.com/articles/s41586-018-0259-z</ref>. This G protein activation results in a cellular response dependent on the ligand bound and location of the GPCR in the body. GCPRs can be broken down into five families: the [https://en.wikipedia.org/wiki/Rhodopsin-like_receptors rhodopsin family (class A)], the [https://en.wikipedia.org/wiki/Secretin_receptor_family secretin family (class B)], the [https://en.wikipedia.org/wiki/Adhesion_G_protein-coupled_receptor adhesion family], the [https://en.wikipedia.org/wiki/Class_C_GPCR glutamate family (class C)], and the [https://en.wikipedia.org/wiki/Frizzled frizzled/taste family (class F)] <ref name="Zhang">PMID: 26467290</ref>. All of the families have a similar transmembrane (TM) domain consisting of seven <scene name='90/904328/7tm_domain_pt_3/7'> 7 α-helices</scene> complexed with intracellular G proteins (Figure 1).
+[https://proteopedia.org/wiki/index.php/G_protein-coupled_receptors G-protein coupled receptors](GCPRs) are a large family of cell surface membrane receptors. Once bound to a wide variety of extracellular ligands, GCPRs undergo a conformational change and relay information to intracellular secondary messengers <ref name="Thal">Thal, David M., et al. "Structural insights into G-protein-coupled receptor allostery." Nature, Nature Publishing Group, 04 July 2018, https://www.nature.com/articles/s41586-018-0259-z</ref>. This G protein activation results in a cellular response dependent on the ligand bound and location of the GPCR in the body. GCPRs can be broken down into five families: the [https://en.wikipedia.org/wiki/Rhodopsin-like_receptors rhodopsin family (class A)], the [https://en.wikipedia.org/wiki/Secretin_receptor_family secretin family (class B)], the [https://en.wikipedia.org/wiki/Adhesion_G_protein-coupled_receptor adhesion family], the [https://en.wikipedia.org/wiki/Class_C_GPCR glutamate family (class C)], and the [https://en.wikipedia.org/wiki/Frizzled frizzled/taste family (class F)] <ref name="Zhang">PMID: 26467290</ref>. All of the families have a similar transmembrane (TM) domain consisting of <scene name='90/904328/7tm_domain_pt_3/7'>seven α-helices</scene> complexed with intracellular G proteins (Figure 1).
 === Class A GCPRs ===