7unk: Difference between revisions
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==Structure of Importin-4 bound to the H3-H4-ASF1 histone-histone chaperone complex== | |||
<StructureSection load='7unk' size='340' side='right'caption='[[7unk]], [[Resolution|resolution]] 3.45Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7unk]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] and [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UNK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UNK FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7unk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7unk OCA], [https://pdbe.org/7unk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7unk RCSB], [https://www.ebi.ac.uk/pdbsum/7unk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7unk ProSAT]</span></td></tr> | |||
[[Category: | </table> | ||
== Function == | |||
[[https://www.uniprot.org/uniprot/H4_XENLA H4_XENLA]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Saccharomyces cerevisiae]] | |||
[[Category: Xenopus laevis]] | |||
[[Category: Bernardes NE]] | |||
[[Category: Chen Z]] | |||
[[Category: Chook YM]] | |||
[[Category: Fung HYJ]] | |||
[[Category: Li Y]] | |||
Revision as of 07:38, 21 September 2022
Structure of Importin-4 bound to the H3-H4-ASF1 histone-histone chaperone complex
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