7sd1: Difference between revisions
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==Crystal structure of SHOC2== | ==Crystal structure of SHOC2== | ||
<StructureSection load='7sd1' size='340' side='right'caption='[[7sd1]]' scene=''> | <StructureSection load='7sd1' size='340' side='right'caption='[[7sd1]], [[Resolution|resolution]] 3.19Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7SD1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7SD1 FirstGlance]. <br> | <table><tr><td colspan='2'>[[7sd1]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7SD1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7SD1 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7sd1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7sd1 OCA], [https://pdbe.org/7sd1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7sd1 RCSB], [https://www.ebi.ac.uk/pdbsum/7sd1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7sd1 ProSAT]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7sd1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7sd1 OCA], [https://pdbe.org/7sd1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7sd1 RCSB], [https://www.ebi.ac.uk/pdbsum/7sd1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7sd1 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | |||
[[https://www.uniprot.org/uniprot/SHOC2_HUMAN SHOC2_HUMAN]] Noonan syndrome-like disorder with loose anagen hair. The disease is caused by variants affecting the gene represented in this entry. | |||
== Function == | |||
[[https://www.uniprot.org/uniprot/SHOC2_HUMAN SHOC2_HUMAN]] Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes.<ref>PMID:10783161</ref> <ref>PMID:16630891</ref> <ref>PMID:25137548</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Hymowitz | [[Category: Hymowitz, S G]] | ||
[[Category: Liau | [[Category: Liau, N P.D]] | ||
[[Category: Sudhamsu J]] | [[Category: Sudhamsu, J]] | ||
[[Category: Pp1c]] | |||
[[Category: Ra]] | |||
[[Category: Scaffold]] | |||
[[Category: Signaling protein]] | |||
