7wji: Difference between revisions
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==== | ==Architecture of the human NALCN channelosome== | ||
<StructureSection load='7wji' size='340' side='right'caption='[[7wji]]' scene=''> | <StructureSection load='7wji' size='340' side='right'caption='[[7wji]], [[Resolution|resolution]] 4.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | <table><tr><td colspan='2'>[[7wji]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WJI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WJI FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wji FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wji OCA], [https://pdbe.org/7wji PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wji RCSB], [https://www.ebi.ac.uk/pdbsum/7wji PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wji ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.5Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wji FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wji OCA], [https://pdbe.org/7wji PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wji RCSB], [https://www.ebi.ac.uk/pdbsum/7wji PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wji ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Disease == | |||
[https://www.uniprot.org/uniprot/UNC80_HUMAN UNC80_HUMAN] Hypotonia-speech impairment-severe cognitive delay syndrome. The disease is caused by variants affecting the gene represented in this entry. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/UNC80_HUMAN UNC80_HUMAN] Auxiliary subunit of the NALCN sodium channel complex, a voltage-gated ion channel responsible for the resting Na(+) permeability that controls neuronal excitability (By similarity). Activated by neuropeptides substance P, neurotensin, and extracellular Ca(2+) that regulates neuronal excitability by controlling the sizes of NALCN-dependent sodium-leak current. UNC80 is essential for NALCN sensitivity to extracellular Ca(2+) (By similarity).[UniProtKB:Q8BLN6] | |||
==See Also== | |||
*[[Calmodulin 3D structures|Calmodulin 3D structures]] | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Z | [[Category: Liu H]] | ||
[[Category: Wu JP]] | |||
[[Category: Yan Z]] | |||
[[Category: Zhao Q]] | |||
[[Category: Zhou L]] | |||
