Sandbox Reserved 1722: Difference between revisions
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This receptor is shallow and is able to bind to a variety of drugs, creating a need for a solution to mediate the effects of MRGPRX2 activation. Currently, there is research for the development of small antagonists that will induce an anti-inflammatory effect by preventing [https://en.wikipedia.org/wiki/Immunoglobulin_E IgE-dependent] mast cell degranulation <ref name="McNeil">McNeil, B. D., et al. "MRGPRX2 and Adverse Drug Reactions." Frontier Immunology, 06 August 2021, https://www.frontiersin.org/articles/10.3389/fimmu.2021.676354/full</ref>. There are two antagonists that have been adapted from being antagonists to another Class A GPCR, [https://en.wikipedia.org/wiki/NK1_receptor_antagonist neurokinin-1 receptor (NK-1R)] <ref name="Ogasawara">Ogasawara, H., et al. "Novel MRGPRX2 antagonists inhibit IgE-independent activation of human umbilical cord blood-derived mast cells." Journal of Leukocyte Biology, 12 July 2019, https://jlb.onlinelibrary.wiley.com/doi/10.1002/JLB.2AB1018-405R</ref>. Through the development of this research, these adverse side effects can be relieved and improve patient satisfaction. | This receptor is shallow and is able to bind to a variety of drugs, creating a need for a solution to mediate the effects of MRGPRX2 activation. Currently, there is research for the development of small antagonists that will induce an anti-inflammatory effect by preventing [https://en.wikipedia.org/wiki/Immunoglobulin_E IgE-dependent] mast cell degranulation <ref name="McNeil">McNeil, B. D., et al. "MRGPRX2 and Adverse Drug Reactions." Frontier Immunology, 06 August 2021, https://www.frontiersin.org/articles/10.3389/fimmu.2021.676354/full</ref>. There are two antagonists that have been adapted from being antagonists to another Class A GPCR, [https://en.wikipedia.org/wiki/NK1_receptor_antagonist neurokinin-1 receptor (NK-1R)] <ref name="Ogasawara">Ogasawara, H., et al. "Novel MRGPRX2 antagonists inhibit IgE-independent activation of human umbilical cord blood-derived mast cells." Journal of Leukocyte Biology, 12 July 2019, https://jlb.onlinelibrary.wiley.com/doi/10.1002/JLB.2AB1018-405R</ref>. Through the development of this research, these adverse side effects can be relieved and improve patient satisfaction. | ||
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== References == | |||
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