Methionine synthase: Difference between revisions
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When B12 is not engaged with one of the other three substrate binding domains, it is protected by a <scene name='90/907471/Cap/1'>cap</scene>. | When B12 is not engaged with one of the other three substrate binding domains, it is protected by a <scene name='90/907471/Cap/1'>cap</scene>. | ||
Conformation changes occur when DMB ligand moves away from the corrin and is replaced by His 759. Without His, the B12 binding domain remains capped.<ref name="bandarian et al"/>. It is suggested the ligand trifecta (His | Conformation changes occur when DMB ligand moves away from the corrin and is replaced by His 759. Without His, the B12 binding domain remains capped.<ref name="bandarian et al"/>. It is suggested the ligand trifecta (His, Asp, Ser) with Cobalamin is what drives the reactivity of MS<ref>DOI: 10.1126/science.7992050</ref>. | ||
== Oxidation States of Cobalamin == | == Oxidation States of Cobalamin == | ||
