Thymidylate synthase: Difference between revisions

Line 18:

==Structure and ligand binding==

TS forms a homodimer consisting of two domains (reload <scene name='49/493689/Cv/1'>initial scene</scene>). Their <scene name='49/493689/Dump_binding/3'>active sites</scene> can each bind the substrate dUMP<ref>PMID:9053905</ref>. The sketch below shows some of the ionic and hydrogen bonding interactions between the protein and the substrate, most of which are also shown in the 3D scene. You can measure distances and angles after turning off the spinning (for detailed instructions, see viewing guide, [https://proteopedia.org/wiki/index.php/Help:Viewing_pages]).

TS forms a homodimer consisting of two domains (reload <scene name='49/493689/Cv/1'>initial scene</scene>). Their <scene name='49/493689/Dump_binding/4'>active sites</scene> can each bind the substrate dUMP<ref>PMID:9053905</ref>. The sketch below shows some of the ionic and hydrogen bonding interactions between the protein and the substrate, most of which are also shown in the 3D scene. You can measure distances and angles after turning off the spinning (for detailed instructions, see viewing guide, [https://proteopedia.org/wiki/index.php/Help:Viewing_pages]).

[[Image:DUMP binding.PNG|400px]]

Thymidylate synthase: Difference between revisions

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@@ Line 18: / Line 18: @@
 <StructureSection load='' size='350' side='right' caption='Thymidylate synthase complex with dUMP (PDB entry [[1tsv]])' scene='49/493689/Cv/1'>
 ==Structure and ligand binding==
-TS forms a homodimer consisting of two domains (reload <scene name='49/493689/Cv/1'>initial scene</scene>). Their <scene name='49/493689/Dump_binding/3'>active sites</scene> can each bind the substrate dUMP<ref>PMID:9053905</ref>. The sketch below shows some of the ionic and hydrogen bonding interactions between the protein and the substrate, most of which are also shown in the 3D scene. You can measure distances and angles after turning off the spinning (for detailed instructions, see viewing guide, [https://proteopedia.org/wiki/index.php/Help:Viewing_pages]).
+TS forms a homodimer consisting of two domains (reload <scene name='49/493689/Cv/1'>initial scene</scene>). Their <scene name='49/493689/Dump_binding/4'>active sites</scene> can each bind the substrate dUMP<ref>PMID:9053905</ref>. The sketch below shows some of the ionic and hydrogen bonding interactions between the protein and the substrate, most of which are also shown in the 3D scene. You can measure distances and angles after turning off the spinning (for detailed instructions, see viewing guide, [https://proteopedia.org/wiki/index.php/Help:Viewing_pages]).
 [[Image:DUMP binding.PNG|400px]]