Methionine synthase: Difference between revisions
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=== Domain organization === | === Domain organization === | ||
Methionine synthase contains four domains, each with a unique function that bind to Cob(I)alamin as the methyl carrier. In the N-terminal, 5-MTHFR donates a methyl in the catalytic cycle to Cob(I)alamin, which then donates it to homocysteine to form methionine. In the C-terminal, S-adenosylmethionine or SAM donates | Methionine synthase contains four domains, each with a unique function that bind to Cob(I)alamin as the methyl carrier. In the N-terminal, 5-MTHFR donates a methyl in the catalytic cycle to Cob(I)alamin, which then donates it to homocysteine to form methionine. However, every 2,000 cycles or so, Cob(I)alamin becomes oxidized and requires reduction and remethylation. In the C-terminal, S-adenosylmethionine or SAM donates methyl in the reactivation cycle with Flavodoxin as the electron donor<ref name="Bandarian et al">DOI: 10.1038/nsb738</ref>. | ||
[[Image:Methionine synthase domains.gif]] | [[Image:Methionine synthase domains.gif]] | ||
