LCE1a2: Difference between revisions

Line 23:

Although the direct capabilities of the proteins coded for via the LCE clusters are still not known, the information provided above gives not only background of the topic of LCE’s but also provides a look into the structure and properties of a protein from LCE1a2 cluster. In addition to the characteristics of a protein found within the gene cluster, the steps used to find and analyze the protein was given. Alongside the protein, a clonal sequence was produced to provide additional sequence characteristics such as melting point and complexity. Those results can be found ''[here]https://docs.google.com/document/d/1ksBWboifsRKvl51sPhwnniiDPmeDZDxTF9RiGZhm24c/edit?usp=sharing''.

== Structural highlights ==

== Structural highlights from other proteins coded in this region ==

late_cornified_envelope_protein_1C-like_[Onychomys_torridus] [http://www.sbg.bio.ic.ac.uk/phyre2/phyre2_output/d23e1a6315d96171/final.casp.pdb]

small_proline_rich-like_2,_partial_[Mus_musculus]

small_proline_rich-like_3,_partial_[Mus_musculus]

late_cornified_envelope_1A1_[Mus_musculus].

== Conclusion ==

Line 37:

Line 42:

Henry, J., Toulza, E., Hsu, C. Y., Pellerin, L., Balica, S., Mazereeuw-Hautier, J., Paul, C., Serre, G., Jonca, N., & Simon, M. (2012). Update on the epidermal differentiation complex. Frontiers in bioscience (Landmark edition), 17, 1517– 1532.https://doi.org/10.2741/401

Jackson, B., Tilli, C. M., Hardman, M. J., Avilion, A. A., MacLeod, M. C., Ashcroft, G. S., & Byrne, C. (2005). Late cornified envelope family in differentiating epithelia-response to calcium and ultraviolet irradiation. The Journal of investigative dermatology, 124(5), 1062–1070. https://doi.org/10.1111/j.0022202X.2005.23699.x

Lehrer RI, Barton A, Daher KA, Harwig SS, Ganz T, Selsted ME. Interaction of human defensins with Escherichia coli. Mechanism of bactericidal activity. J Clin Invest. 1989;84:553–61.

Moreci, R. S., & Lechler, T. (2020). Epidermal structure and differentiation. Current biology : CB, 30(4), R144–R149. https://doi.org/10.1016/j.cub.2020.01.004

Niehues, H., Tsoi, L. C., van der Krieken, D. A., Jansen, P., Oortveld, M., RodijkOlthuis, D., van Vlijmen, I., Hendriks, W., Helder, R. W., Bouwstra, J. A., van den Bogaard, E. H., Stuart, P. E., Nair, R. P., Elder, J. T., Zeeuwen, P., & Schalkwijk, J. (2017). Psoriasis-Associated Late Cornified Envelope (LCE) Proteins Have Antibacterial Activity. The Journal of investigative dermatology, 137(11), 2380– 2388. https://doi.org/10.1016/j.jid.2017.06.003

Niehues, H., Tsoi, L. C., van der Krieken, D. A., Jansen, P., Oortveld, M., RodijkOlthuis, D., van Vlijmen, I., Hendriks, W., Helder, R. W., Bouwstra, J. A., van den Bogaard, E.

H., Stuart, P. E., Nair, R. P., Elder, J. T., Zeeuwen, P., & Schalkwijk, J. (2017). Psoriasis-Associated Late Cornified Envelope (LCE) Proteins Have Antibacterial Activity. The Journal of investigative dermatology, 137(11), 2380– 2388. https://doi.org/10.1016/j.jid.2017.06.003

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@@ Line 23: / Line 23: @@
 Although the direct capabilities of the proteins coded for via the LCE clusters are still not known, the information provided above gives not only background of the topic of LCE’s but also provides a look into the structure and properties of a protein from LCE1a2 cluster. In addition to the characteristics of a protein found within the gene cluster, the steps used to find and analyze the protein was given. Alongside the protein, a clonal sequence was produced to provide additional sequence characteristics such as melting point and complexity. Those results can be found ''[here]https://docs.google.com/document/d/1ksBWboifsRKvl51sPhwnniiDPmeDZDxTF9RiGZhm24c/edit?usp=sharing''.
-== Structural highlights ==
+== Structural highlights from other proteins coded in this region ==
+late_cornified_envelope_protein_1C-like_[Onychomys_torridus] [http://www.sbg.bio.ic.ac.uk/phyre2/phyre2_output/d23e1a6315d96171/final.casp.pdb]
+small_proline_rich-like_2,_partial_[Mus_musculus]
+small_proline_rich-like_3,_partial_[Mus_musculus]
+late_cornified_envelope_1A1_[Mus_musculus].
 == Conclusion ==
@@ Line 37: / Line 42: @@
 <references/>
 Henry, J., Toulza, E., Hsu, C. Y., Pellerin, L., Balica, S., Mazereeuw-Hautier, J., Paul, C., Serre, G., Jonca, N., & Simon, M. (2012). Update on the epidermal differentiation complex. Frontiers in bioscience (Landmark edition), 17, 1517– 1532.https://doi.org/10.2741/401
 Jackson, B., Tilli, C. M., Hardman, M. J., Avilion, A. A., MacLeod, M. C., Ashcroft, G. S., & Byrne, C. (2005). Late cornified envelope family in differentiating epithelia-response to calcium and ultraviolet irradiation. The Journal of investigative dermatology, 124(5), 1062–1070. https://doi.org/10.1111/j.0022202X.2005.23699.x
 Lehrer RI, Barton A, Daher KA, Harwig SS, Ganz T, Selsted ME. Interaction of human defensins with Escherichia coli. Mechanism of bactericidal activity. J Clin Invest. 1989;84:553–61.
 Moreci, R. S., & Lechler, T. (2020). Epidermal structure and differentiation. Current biology : CB, 30(4), R144–R149. https://doi.org/10.1016/j.cub.2020.01.004
-Niehues, H., Tsoi, L. C., van der Krieken, D. A., Jansen, P., Oortveld, M., RodijkOlthuis, D., van Vlijmen, I., Hendriks, W., Helder, R. W., Bouwstra, J. A., van den Bogaard, E. H., Stuart, P. E., Nair, R. P., Elder, J. T., Zeeuwen, P., & Schalkwijk,  J. (2017). Psoriasis-Associated Late Cornified Envelope (LCE) Proteins Have Antibacterial Activity. The Journal of investigative dermatology, 137(11), 2380– 2388. https://doi.org/10.1016/j.jid.2017.06.003
+Niehues, H., Tsoi, L. C., van der Krieken, D. A., Jansen, P., Oortveld, M., RodijkOlthuis, D., van Vlijmen, I., Hendriks, W., Helder, R. W., Bouwstra, J. A., van den Bogaard, E.
+H., Stuart, P. E., Nair, R. P., Elder, J. T., Zeeuwen, P., & Schalkwijk,  J. (2017). Psoriasis-Associated Late Cornified Envelope (LCE) Proteins Have Antibacterial Activity. The Journal of investigative dermatology, 137(11), 2380– 2388. https://doi.org/10.1016/j.jid.2017.06.003