User:Brian Boyle/Sandbox 1: Difference between revisions
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Brian Boyle (talk | contribs) New page: <StructureSection load='5o5a' size='350' side='right' caption='BRPF1 Bromodomain in complex with inhibitor BZ054. (PDB entry 5o5a)' scene=''> == '''Overview''' == '''Peregrin''', a... |
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== '''Acetyllysine Binding''' == | == '''Acetyllysine Binding''' == | ||
The BRPF1 bromodomain has been shown to recognize and bind to various acetylated lysine marks on the N-terminal tails of histones tails <ref name="Glass1" />. Using isothermal titration calorimetry (ITC) experiments, it was found that the BRPF1 bromodomain preferentially binds to histone H4 acetylated at positions K5 and K8 as well as H2A at position K5 <ref name="Obi" />, <ref>PMID:24333487</ref> | The BRPF1 bromodomain has been shown to recognize and bind to various acetylated lysine marks on the N-terminal tails of histones tails <ref name="Glass1" />. Using isothermal titration calorimetry (ITC) experiments, it was found that the BRPF1 bromodomain preferentially binds to histone H4 acetylated at positions K5 and K8 as well as H2A at position K5 (see [[4QYL]]) <ref name="Obi" />, <ref>PMID:24333487</ref> | ||
== '''Role in Disease Progression''' == | == '''Role in Disease Progression''' == | ||
