7xe2: Difference between revisions

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'''Unreleased structure'''


The entry 7xe2 is ON HOLD  until Paper Publication
==Crystal structure of LSD2 in complex with compound 1t==
 
<StructureSection load='7xe2' size='340' side='right'caption='[[7xe2]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
Authors: Niwa, H., Sato, S., Umehara, T.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[7xe2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XE2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XE2 FirstGlance]. <br>
Description: Crystal structure of LSD2 in complex with compound 1t
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DIJ:3-(4-bromophenyl)propanal'>DIJ</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xe2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xe2 OCA], [https://pdbe.org/7xe2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xe2 RCSB], [https://www.ebi.ac.uk/pdbsum/7xe2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xe2 ProSAT]</span></td></tr>
[[Category: Niwa, H]]
</table>
[[Category: Sato, S]]
== Function ==
[[Category: Umehara, T]]
[[https://www.uniprot.org/uniprot/KDM1B_HUMAN KDM1B_HUMAN]] Histone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of imprinted genes during oogenesis. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. Has no effect on tri-methylated 'Lys-4', mono-, di- or tri-methylated 'Lys-9', mono-, di- or tri-methylated 'Lys-27', mono-, di- or tri-methylated 'Lys-36' of histone H3, or on mono-, di- or tri-methylated 'Lys-20' of histone H4 (By similarity).
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Niwa H]]
[[Category: Sato S]]
[[Category: Umehara T]]
Retrieved from "https://proteopedia.org/7xe2"