ALDH2: Difference between revisions
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Homotetramer functioning as dimer of dimers. <ref name="nov2020">DOI: 10.1016/j.ebiom.2020.102753</ref> | Homotetramer functioning as dimer of dimers. <ref name="nov2020">DOI: 10.1016/j.ebiom.2020.102753</ref> | ||
</StructureSection> | </StructureSection> | ||
== Function == | == Function == | ||
Detoxifying of toxic aldehydes, involved in many pathways such as ethanol breakdown, lipid metabolization, role in oxidative stress of cell. | <StructureSection load='1CW3' size='250' side='right' caption='active site of A-chain of human mitochondrial ALDH2 complexed with NAD+ (PDB entry [http://doi.org/10.2210/pdb1CW3/pdb 1CW3])' scene='76/763091/Aldh2_active_site_a-chain/2'> | ||
Detoxifying of toxic aldehydes, involved in many pathways such as ethanol breakdown, lipid metabolization, role in oxidative stress of cell. <ref name="nov2020">DOI: 10.1016/j.ebiom.2020.102753</ref> | |||
</StructureSection> | |||
== Mutations == | == Mutations == | ||
<StructureSection load='3INL' size='350' side='right' caption='Human Mitochondrial Aldehyde Dehydrogenase Asian Variant, ALDH2*2, complexed with agonist Alda-1 (PDB entry [http://doi.org/10.2210/pdb3INL/pdb 3INL])' scene=''> | <StructureSection load='3INL' size='350' side='right' caption='Human Mitochondrial Aldehyde Dehydrogenase Asian Variant, ALDH2*2, complexed with agonist Alda-1 (PDB entry [http://doi.org/10.2210/pdb3INL/pdb 3INL])' scene=''> | ||
