Ceramidase: Difference between revisions
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Refs <ref name="Okino">PMID:9603946</ref>, <ref name="Inoue">PMID:19088069</ref> , <ref name="Reverse">PMID:10832092</ref> | Refs <ref name="Okino">PMID:9603946</ref>, <ref name="Inoue">PMID:19088069</ref> , <ref name="Reverse">PMID:10832092</ref> | ||
== Structural highlights == | |||
CerN consists of two domains: a catalytic domain near the N-terminal and an immunoglobulin-fold domain near the C-terminal. Three β-sheets, each formed from four β-strands, compose a β-prism fold at the center of the N-terminal domain. Surrounding the β-prism fold are 11 α-helices, forming an α+ β 2-layer sandwich fold. The immunoglobulin C-terminal domain is composed of two β-sheets, containing four β-strands each, forming a β-sandwich fold. Between the N- and C-terminal domains is a magnesium/calcium ion binding site that links together the two domains. His37, Asp579, Asp581, and Thr854 interact with divalent cations within the magnesium/calcium ion binding site. A second metal-binding site containing a zinc ion is located within the N-terminal domain active site, where it is coordinated by His97, His204, Glu411, and a water molecule. | |||
This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | ||
<table><tr><td colspan='2'>[[2zxc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZXC OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2ZXC FirstGlance]. <br> | <table><tr><td colspan='2'>[[2zxc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZXC OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2ZXC FirstGlance]. <br> | ||
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2zxc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zxc OCA], [http://pdbe.org/2zxc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zxc RCSB], [http://www.ebi.ac.uk/pdbsum/2zxc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2zxc ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2zxc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zxc OCA], [http://pdbe.org/2zxc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zxc RCSB], [http://www.ebi.ac.uk/pdbsum/2zxc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2zxc ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | |||
p<ref name="Okino">PMID:9603946</ref> | |||
== Relevance == | |||
p | |||
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||
