Methionine synthase: Difference between revisions
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'''Methionine synthase''' (MS; EC: 2.1.1.13) is the enzyme in [[one-carbon metabolism]] linking the folate cycle to the methionine cycle. MS catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate (5- me THF) to homocysteine, resulting in the formation of methionine. Methionine is an essential amino acid required by our bodies for healthy cell and tissue growth. It is essential as it is not naturally derived in our bodies. As it is used as a methyl donor in the form of S-adenosylmethionine, the resulting homocysteine is recyled to form methionine again. | '''Methionine synthase''' (MS; EC: 2.1.1.13) is the enzyme in [[one-carbon metabolism]] linking the folate cycle to the methionine cycle. MS catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate (5- me THF) to homocysteine, resulting in the formation of methionine. Methionine is an essential amino acid required by our bodies for healthy cell and tissue growth. It is essential as it is not naturally derived in our bodies. As it is used as a methyl donor in the form of S-adenosylmethionine, the resulting homocysteine is recyled to form methionine again. | ||
[[Image:Overall.jpg]] | [[Image:Overall.jpg]]<scene name='90/907471/Superposition_1/2'>Text To Be Displayed</scene> | ||
==Function== | ==Function== | ||
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== Structural highlights == | == Structural highlights == | ||
<StructureSection load='1k7y' size='310' side='right' caption='C-terminal fragment of MS (PDB ID: 1k7y)' scene=''> | <StructureSection load='<scene name='90/907471/Superposition_1/2'>1k7y</scene>' size='310' side='right' caption='C-terminal fragment of MS (PDB ID: 1k7y)' scene=''> | ||
<scene name='90/907471/Superposition_1/2'>Text To Be Displayed</scene>' size='310' side='right' caption='N-terminal containing catalytic cycle with two domains: 5-me THF and Hcy. C-terminal containing reactivation cycle with two domains: Cobalamin and SAM' (PBD ID: 1k7y)' scene=''> | |||
=== Domain organization === | === Domain organization === | ||
