GLUT1: Difference between revisions
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===Diabetes=== | ===Diabetes=== | ||
====Diabetes and Pregnancy==== | ====Diabetes and Pregnancy==== | ||
GLUT1 has been shown to be upregulated in the placental tissue of mothers with both pregestational and gestational diabetes, even when a patient's glycemic control is good. It is hypothesized that fetal hyperglycemia due to increased glucose transporter expression.<ref>PMID:10022440</ref> | GLUT1 has been shown to be upregulated in the placental tissue of mothers with both pregestational and gestational diabetes, even when a patient's glycemic control is considered good. It is hypothesized that fetal hyperglycemia due to increased glucose transporter expression.<ref>PMID:10022440</ref> | ||
== | ====Diabetic Retinopathy==== | ||
GLUT1 has been found to be upregulated in retinal tissue of diabetic mice. Studies on mice show that GLUT1 overexpression plays a key role in development of diabetic retinopathy.<ref>PMID:33622781</ref> While it has been proven that hyperglycemia causes diabetic retinopathy in humans, more research is necessary to determine if GLUT1 plays a direct role in diabetic retinopathy. | |||
== Structural highlights == | == Structural highlights == | ||
