GLUT1: Difference between revisions
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==Facilitated Glucose Transporter 1, Solute Carrier Family 2, ''Homo sapiens''== | ==Facilitated Glucose Transporter 1, Solute Carrier Family 2, ''Homo sapiens''== | ||
<StructureSection load='4pyp' size='340' side='right' caption=' | <StructureSection load='4pyp' size='340' side='right' caption='Glucose ABC transporter complex with nonyl beta-D-glucopyranoside (PDB code [[4pyp]])' scene=''> | ||
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== Classification == | == Classification == | ||
GLUT proteins, encoded by the [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104978/ SLC2] genes, are part of the Major Facilitator Superfamily (MFS) of substrate transporters. Structural elements characteristic of GLUT proteins are twelve transmembrane domains, one N-linked glycosylation site, and lengths of about five-hundred amino acids.<ref>PMID:23506862</ref> GLUT proteins transport a variety of monosaccharides that enable cellular respiration and are thus abundant in the body. Referencing the [http://cathdb.info/version/v4_3_0/superfamily/1.20.1250.20 CATH] classification database, the MFS superfamily has 23,982 unique species and 134 characteristic domains. GLUT1 has two highly-conserved ATP-binding domains known as Walker motifs A and B.<ref>PMID:15326030</ref> A third ATP-binding domain is less conserved. According to [https://www.uniprot.org/uniprot/?query=job:P2022050392C7BAECDB1C5C413EE0E0348724B682005B3CL&columns=id,entry%20name,reviewed,protein%20names,genes,organism,length,peptidesearch(P2022050392C7BAECDB1C5C413EE0E0348724B682005B3CL) UniProt], these specific sequences in the GLUT1 transporter are shared among glucose transporters in several different organisms. | GLUT proteins, encoded by the [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104978/ SLC2] genes, are part of the Major Facilitator Superfamily (MFS) of substrate transporters. Structural elements characteristic of GLUT proteins are twelve transmembrane domains, one N-linked glycosylation site, and lengths of about five-hundred amino acids.<ref>PMID:23506862</ref> GLUT proteins transport a variety of monosaccharides that enable cellular respiration and are thus abundant in the body. Referencing the [http://cathdb.info/version/v4_3_0/superfamily/1.20.1250.20 CATH] classification database, the MFS superfamily has 23,982 unique species and 134 characteristic domains. GLUT1 has two highly-conserved ATP-binding domains known as Walker motifs A and B.<ref>PMID:15326030</ref> A third ATP-binding domain is less conserved. According to [https://www.uniprot.org/uniprot/?query=job:P2022050392C7BAECDB1C5C413EE0E0348724B682005B3CL&columns=id,entry%20name,reviewed,protein%20names,genes,organism,length,peptidesearch(P2022050392C7BAECDB1C5C413EE0E0348724B682005B3CL) UniProt], these specific sequences in the GLUT1 transporter are shared among glucose transporters in several different organisms. | ||
== Function == | == Function == | ||
