1esl: Difference between revisions
New page: left|200px<br /> <applet load="1esl" size="450" color="white" frame="true" align="right" spinBox="true" caption="1esl, resolution 2.0Å" /> '''INSIGHT INTO E-SELEC... |
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[[Image:1esl.gif|left|200px]]<br /> | [[Image:1esl.gif|left|200px]]<br /><applet load="1esl" size="350" color="white" frame="true" align="right" spinBox="true" | ||
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caption="1esl, resolution 2.0Å" /> | caption="1esl, resolution 2.0Å" /> | ||
'''INSIGHT INTO E-SELECTIN(SLASH)LIGAND INTERACTION FROM THE CRYSTAL STRUCTURE AND MUTAGENESIS OF THE LEC(SLASH)EGF DOMAINS'''<br /> | '''INSIGHT INTO E-SELECTIN(SLASH)LIGAND INTERACTION FROM THE CRYSTAL STRUCTURE AND MUTAGENESIS OF THE LEC(SLASH)EGF DOMAINS'''<br /> | ||
==Overview== | ==Overview== | ||
The three-dimensional structure of the ligand-binding region of human | The three-dimensional structure of the ligand-binding region of human E-selectin has been determined at 2.0 A resolution. The structure reveals limited contact between the two domains and a coordination of Ca2+ not predicted from other C-type lectins. Structure/function analysis indicates a defined region and specific amino-acid side chains that may be involved in ligand binding. These features of the E-selectin/ligand interaction have important implications for understanding the recruitment of leukocytes to sites of inflammation. | ||
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
1ESL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with CA and CL as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | 1ESL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=CA:'>CA</scene> and <scene name='pdbligand=CL:'>CL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ESL OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Crowther, R | [[Category: Crowther, R L.]] | ||
[[Category: Graves, B | [[Category: Graves, B J.]] | ||
[[Category: CA]] | [[Category: CA]] | ||
[[Category: CL]] | [[Category: CL]] | ||
[[Category: cell adhesion protein]] | [[Category: cell adhesion protein]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:31:06 2008'' | ||
Revision as of 10:31, 21 February 2008
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INSIGHT INTO E-SELECTIN(SLASH)LIGAND INTERACTION FROM THE CRYSTAL STRUCTURE AND MUTAGENESIS OF THE LEC(SLASH)EGF DOMAINS
Overview
The three-dimensional structure of the ligand-binding region of human E-selectin has been determined at 2.0 A resolution. The structure reveals limited contact between the two domains and a coordination of Ca2+ not predicted from other C-type lectins. Structure/function analysis indicates a defined region and specific amino-acid side chains that may be involved in ligand binding. These features of the E-selectin/ligand interaction have important implications for understanding the recruitment of leukocytes to sites of inflammation.
Disease
Known diseases associated with this structure: Atherosclerosis, susceptibility to OMIM:[131210], Blood pressure regulation QTL OMIM:[131210], IgA nephropathy, susceptiblity to OMIM:[131210]
About this Structure
1ESL is a Single protein structure of sequence from Homo sapiens with CA and CL as ligands. Full crystallographic information is available from OCA.
Reference
Insight into E-selectin/ligand interaction from the crystal structure and mutagenesis of the lec/EGF domains., Graves BJ, Crowther RL, Chandran C, Rumberger JM, Li S, Huang KS, Presky DH, Familletti PC, Wolitzky BA, Burns DK, Nature. 1994 Feb 10;367(6463):532-8. PMID:7509040
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