7zej: Difference between revisions
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==Crystal structure of the human MGC45594 gene product in complex with celecoxib.== | ==Crystal structure of the human MGC45594 gene product in complex with celecoxib.== | ||
<StructureSection load='7zej' size='340' side='right'caption='[[7zej]]' scene=''> | <StructureSection load='7zej' size='340' side='right'caption='[[7zej]], [[Resolution|resolution]] 1.79Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZEJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZEJ FirstGlance]. <br> | <table><tr><td colspan='2'>[[7zej]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZEJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZEJ FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zej FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zej OCA], [https://pdbe.org/7zej PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zej RCSB], [https://www.ebi.ac.uk/pdbsum/7zej PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zej ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.79Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CEL:4-[5-(4-METHYLPHENYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL]BENZENESULFONAMIDE'>CEL</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zej FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zej OCA], [https://pdbe.org/7zej PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zej RCSB], [https://www.ebi.ac.uk/pdbsum/7zej PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zej ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/PTGR3_HUMAN PTGR3_HUMAN] Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest efficiency towards 15-keto-PGE2-alpha. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation.[UniProtKB:Q8BGC4] | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Arrowsmith C]] | [[Category: Arrowsmith C]] | ||
