7m0g: Difference between revisions
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==Magic Angle Spinning NMR Structure of Human Cofilin-2 Assembled on Actin Filaments== | ==Magic Angle Spinning NMR Structure of Human Cofilin-2 Assembled on Actin Filaments== | ||
<StructureSection load='7m0g' size='340' side='right'caption='[[7m0g | <StructureSection load='7m0g' size='340' side='right'caption='[[7m0g]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[7m0g]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7M0G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7M0G FirstGlance]. <br> | <table><tr><td colspan='2'>[[7m0g]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7M0G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7M0G FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7m0g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7m0g OCA], [https://pdbe.org/7m0g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7m0g RCSB], [https://www.ebi.ac.uk/pdbsum/7m0g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7m0g ProSAT]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7m0g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7m0g OCA], [https://pdbe.org/7m0g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7m0g RCSB], [https://www.ebi.ac.uk/pdbsum/7m0g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7m0g ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
[https://www.uniprot.org/uniprot/COF2_HUMAN COF2_HUMAN] Typical nemaline myopathy. The disease is caused by variants affecting the gene represented in this entry. | |||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/COF2_HUMAN COF2_HUMAN] Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. Its F-actin depolymerization activity is regulated by association with CSPR3 (PubMed:19752190). It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods. Required for muscle maintenance. May play a role during the exchange of alpha-actin forms during the early postnatal remodeling of the sarcomere (By similarity).[UniProtKB:P45591]<ref>PMID:19752190</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Kraus | [[Category: Kraus J]] | ||
[[Category: Perilla | [[Category: Perilla JP]] | ||
[[Category: Polenova | [[Category: Polenova T]] | ||
[[Category: Xu | [[Category: Xu C]] | ||
Latest revision as of 11:16, 14 June 2023
Magic Angle Spinning NMR Structure of Human Cofilin-2 Assembled on Actin Filaments
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