2z8m: Difference between revisions
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<StructureSection load='2z8m' size='340' side='right'caption='[[2z8m]], [[Resolution|resolution]] 2.00Å' scene=''> | <StructureSection load='2z8m' size='340' side='right'caption='[[2z8m]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2z8m]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z8M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Z8M FirstGlance]. <br> | <table><tr><td colspan='2'>[[2z8m]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z8M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Z8M FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2z8m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z8m OCA], [https://pdbe.org/2z8m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2z8m RCSB], [https://www.ebi.ac.uk/pdbsum/2z8m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2z8m ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2z8m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z8m OCA], [https://pdbe.org/2z8m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2z8m RCSB], [https://www.ebi.ac.uk/pdbsum/2z8m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2z8m ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/SPVC_SALTY SPVC_SALTY] Secreted effector that irreversibly inactivates host MAP kinases by catalyzing the dephosphorylation of the phosphothreonine residue in the pT-X-pY motif in MAPK2/ERK2, MAPK3/ERK1, and p38, via a beta-elimination reaction leading to a dehydrobutyrine residue. Is also able to remove the phosphate group from phospho-JNK in vitro, but JNK may not be a substrate in vivo. Could help suppress localized proinflammatory responses at infection foci in the spleen and liver, and thereby facilitate bacterial growth.<ref>PMID:17303758</ref> <ref>PMID:18060821</ref> <ref>PMID:18084305</ref> <ref>PMID:18284579</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Chai | [[Category: Salmonella enterica subsp. enterica serovar Typhimurium]] | ||
[[Category: Chen | [[Category: Chai J]] | ||
[[Category: Gu | [[Category: Chen L]] | ||
[[Category: Huang | [[Category: Gu L]] | ||
[[Category: Wang | [[Category: Huang N]] | ||
[[Category: Zhou | [[Category: Wang H]] | ||
[[Category: Zhou JM]] | |||
