1h2q: Difference between revisions

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[[Image:1h2q.gif|left|200px]]
{{Seed}}
[[Image:1h2q.png|left|200px]]


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{{STRUCTURE_1h2q|  PDB=1h2q  |  SCENE=  }}  
{{STRUCTURE_1h2q|  PDB=1h2q  |  SCENE=  }}  


'''HUMAN CD55 DOMAINS 3 & 4'''
===HUMAN CD55 DOMAINS 3 & 4===




==Overview==
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Decay-accelerating factor (CD55), a regulator of the alternative and classical pathways of complement activation, is expressed on all serum-exposed cells. It is used by pathogens, including many enteroviruses and uropathogenic Escherichia coli, as a receptor prior to infection. We describe the x-ray structure of a pathogen-binding fragment of human CD55 at 1.7 A resolution containing two of the three domains required for regulation of human complement. We have used mutagenesis to map biological functions onto the molecule; decay-accelerating activity maps to a single face of the molecule, whereas bacterial and viral pathogens recognize a variety of different sites on CD55.
The line below this paragraph, {{ABSTRACT_PUBMED_12499389}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 12499389 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12499389}}


==About this Structure==
==About this Structure==
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[[Category: Gpi-anchor]]
[[Category: Gpi-anchor]]
[[Category: Ligand for cd97]]
[[Category: Ligand for cd97]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:21:13 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 06:31:33 2008''

Revision as of 03:31, 1 July 2008

File:1h2q.png

Template:STRUCTURE 1h2q

HUMAN CD55 DOMAINS 3 & 4

Template:ABSTRACT PUBMED 12499389

About this Structure

1H2Q is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Mapping CD55 function. The structure of two pathogen-binding domains at 1.7 A., Williams P, Chaudhry Y, Goodfellow IG, Billington J, Powell R, Spiller OB, Evans DJ, Lea S, J Biol Chem. 2003 Mar 21;278(12):10691-6. Epub 2002 Dec 22. PMID:12499389

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