1evt: Difference between revisions
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New page: left|200px<br /> <applet load="1evt" size="450" color="white" frame="true" align="right" spinBox="true" caption="1evt, resolution 2.80Å" /> '''CRYSTAL STRUCTURE O... |
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[[Image:1evt.gif|left|200px]]<br /> | [[Image:1evt.gif|left|200px]]<br /><applet load="1evt" size="350" color="white" frame="true" align="right" spinBox="true" | ||
<applet load="1evt" size=" | |||
caption="1evt, resolution 2.80Å" /> | caption="1evt, resolution 2.80Å" /> | ||
'''CRYSTAL STRUCTURE OF FGF1 IN COMPLEX WITH THE EXTRACELLULAR LIGAND BINDING DOMAIN OF FGF RECEPTOR 1 (FGFR1)'''<br /> | '''CRYSTAL STRUCTURE OF FGF1 IN COMPLEX WITH THE EXTRACELLULAR LIGAND BINDING DOMAIN OF FGF RECEPTOR 1 (FGFR1)'''<br /> | ||
==Overview== | ==Overview== | ||
To elucidate the structural determinants governing specificity in | To elucidate the structural determinants governing specificity in fibroblast growth factor (FGF) signaling, we have determined the crystal structures of FGF1 and FGF2 complexed with the ligand binding domains (immunoglobulin-like domains 2 [D2] and 3 [D3]) of FGF receptor 1 (FGFR1) and FGFR2, respectively. Highly conserved FGF-D2 and FGF-linker (between D2-D3) interfaces define a general binding site for all FGF-FGFR complexes. Specificity is achieved through interactions between the N-terminal and central regions of FGFs and two loop regions in D3 that are subject to alternative splicing. These structures provide a molecular basis for FGF1 as a universal FGFR ligand and for modulation of FGF-FGFR specificity through primary sequence variations and alternative splicing. | ||
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
1EVT is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with SO4 as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | 1EVT is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EVT OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Hubbard, S | [[Category: Hubbard, S R.]] | ||
[[Category: Mohammadi, M.]] | [[Category: Mohammadi, M.]] | ||
[[Category: Plotnikov, A | [[Category: Plotnikov, A N.]] | ||
[[Category: Schlessinger, J.]] | [[Category: Schlessinger, J.]] | ||
[[Category: SO4]] | [[Category: SO4]] | ||
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[[Category: immunoglobulin (ig) like domains belonging to the i-set subgroup within ig-like domains]] | [[Category: immunoglobulin (ig) like domains belonging to the i-set subgroup within ig-like domains]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:32:02 2008'' | ||
