3nfb: Difference between revisions

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<StructureSection load='3nfb' size='340' side='right'caption='[[3nfb]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
<StructureSection load='3nfb' size='340' side='right'caption='[[3nfb]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3nfb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Ccug_52537 Ccug 52537]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NFB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NFB FirstGlance]. <br>
<table><tr><td colspan='2'>[[3nfb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Sphingosinicella_xenopeptidilytica Sphingosinicella xenopeptidilytica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NFB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NFB FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=OAE:(2S,4S)-2-[(R)-{[(2R)-2-AMINO-2-PHENYLACETYL]AMINO}(CARBOXY)METHYL]-5,5-DIMETHYL-1,3-THIAZOLIDINE-4-CARBOXYLIC+ACID'>OAE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3n2w|3n2w]], [[3ndv|3ndv]], [[3n33|3n33]], [[1b65|1b65]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=OAE:(2S,4S)-2-[(R)-{[(2R)-2-AMINO-2-PHENYLACETYL]AMINO}(CARBOXY)METHYL]-5,5-DIMETHYL-1,3-THIAZOLIDINE-4-CARBOXYLIC+ACID'>OAE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">bapA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=364098 CCUG 52537])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nfb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nfb OCA], [https://pdbe.org/3nfb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nfb RCSB], [https://www.ebi.ac.uk/pdbsum/3nfb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nfb ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nfb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nfb OCA], [https://pdbe.org/3nfb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nfb RCSB], [https://www.ebi.ac.uk/pdbsum/3nfb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nfb ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/BAPA_SPHXN BAPA_SPHXN]] Beta-aminopeptidase that can cleave synthetic beta-peptides which consist of backbone-elongated beta-amino acid residues that are not processed by common proteolytic enzymes. Can cleave the beta-peptides beta-homoVal-beta-homoAla-beta-homoLeu and beta-homoAla-beta-homoLeu. Requires a beta-amino acid at the N-terminus of peptide substrates and cleaves the peptide bond between the N-terminal beta-amino acid and the amino acid at the second position of tripeptidic substrates of the general structure H-betahXaa-Ile-betahTyr-OH according to the following preferences with regard to the side chain of the N-terminal beta-amino acid: aliphatic and aromatic > OH-containing > hydrogen, basic and polar.<ref>PMID:16109932</ref> <ref>PMID:17064315</ref>
[https://www.uniprot.org/uniprot/BAPA_SPHXN BAPA_SPHXN] Beta-aminopeptidase that can cleave synthetic beta-peptides which consist of backbone-elongated beta-amino acid residues that are not processed by common proteolytic enzymes. Can cleave the beta-peptides beta-homoVal-beta-homoAla-beta-homoLeu and beta-homoAla-beta-homoLeu. Requires a beta-amino acid at the N-terminus of peptide substrates and cleaves the peptide bond between the N-terminal beta-amino acid and the amino acid at the second position of tripeptidic substrates of the general structure H-betahXaa-Ile-betahTyr-OH according to the following preferences with regard to the side chain of the N-terminal beta-amino acid: aliphatic and aromatic > OH-containing > hydrogen, basic and polar.<ref>PMID:16109932</ref> <ref>PMID:17064315</ref>  


==See Also==
==See Also==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Ccug 52537]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Geueke, B]]
[[Category: Sphingosinicella xenopeptidilytica]]
[[Category: Gruetter, M G]]
[[Category: Geueke B]]
[[Category: Heck, T]]
[[Category: Gruetter MG]]
[[Category: Kohler, H P.E]]
[[Category: Heck T]]
[[Category: Merz, T]]
[[Category: Kohler H-PE]]
[[Category: Alpha-beta-beta-alpha sandwich]]
[[Category: Merz T]]
[[Category: Beta-peptide cleaving enzyme]]
[[Category: Hydrolase-inhibitor complex]]
[[Category: Ntn-hydrolase]]
Retrieved from "https://proteopedia.org/3nfb"