1h3z: Difference between revisions

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[[Image:1h3z.~~jpg~~|left|200px]]

[[Image:1h3z.png|left|200px]]

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~~'''~~SOLUTION STRUCTURE OF A PWWP DOMAIN FROM SCHIZOSACCHAROMYCES POMBE~~'''~~

===SOLUTION STRUCTURE OF A PWWP DOMAIN FROM SCHIZOSACCHAROMYCES POMBE===

~~==Overview==~~

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The PWWP domain is a ubiquitous eukaryotic protein module characterised by a region of sequence similarity of approximately 80 amino acids containing a highly conserved PWWP motif. It is frequently found in proteins associated with chromatin. We have determined the ~~structure of a PWWP domain from~~ the S. ~~pombe protein SPBC215~~.~~07c using NMR spectroscopy. The structure~~ is ~~composed of a five stranded beta barrel followed by two alpha helices~~. ~~Comparison to the recently reported structure of a homologous domain from the mammalian DNA methyltransferase Dnmt3b reveals substantial differences both in the C~~-~~terminal helical region and in the PWWP motif.~~

The line below this paragraph, {{ABSTRACT_PUBMED_12842472}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 12842472 is the PubMed ID number.

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==About this Structure==

1H3Z is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H3Z OCA].

1H3Z is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H3Z OCA].

==Reference==

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[[Category: Chromatin]]

[[Category: Pwwp]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May~~ ~~2 18~~:24:11 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 06:35:01 2008''

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-[[Image:1h3z.jpg|left|200px]]
+{{Seed}}
+[[Image:1h3z.png|left|200px]]
 <!--
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 {{STRUCTURE_1h3z|  PDB=1h3z  |  SCENE=  }}
-'''SOLUTION STRUCTURE OF A PWWP DOMAIN FROM SCHIZOSACCHAROMYCES POMBE'''
+===SOLUTION STRUCTURE OF A PWWP DOMAIN FROM SCHIZOSACCHAROMYCES POMBE===
-==Overview==
+<!--
-The PWWP domain is a ubiquitous eukaryotic protein module characterised by a region of sequence similarity of approximately 80 amino acids containing a highly conserved PWWP motif. It is frequently found in proteins associated with chromatin. We have determined the structure of a PWWP domain from the S. pombe protein SPBC215.07c using NMR spectroscopy. The structure is composed of a five stranded beta barrel followed by two alpha helices. Comparison to the recently reported structure of a homologous domain from the mammalian DNA methyltransferase Dnmt3b reveals substantial differences both in the C-terminal helical region and in the PWWP motif.
+The line below this paragraph, {{ABSTRACT_PUBMED_12842472}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 12842472 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_12842472}}
 ==About this Structure==
-H3Z is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H3Z OCA].
+H3Z is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H3Z OCA].
 ==Reference==
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 [[Category: Chromatin]]
 [[Category: Pwwp]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 18:24:11 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 06:35:01 2008''