Biological Unit: Difference between revisions

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The [http://www.ebi.ac.uk/msd-srv/prot_int/pistart.html Protein Interfaces, Surfaces and Assemblies Server] (PISA) at the European Bioinformatics Institute uses improved methods to predict the biological unit or probable quaternary assembly, compared to its predecessor PQS (see next section). These servers examine the contacts that occur in macromolecular crystals used in [[X-ray crystallography]]. They attempt to discriminate between [[crystal contacts]] (artifacts of crystallization) and contacts between chains that have co-evolved to maintain specific oligomeric binding.

===Software: Evolutionary Protein-Protein Interface Classifier (EPPIC)===

The [https://www.eppic-web.org/ewui/ Evolutionary Protein Protein Interface Classifier Server] (EPPIC) classifies all protein-protein contacts in crystal lattices as biologically relevant or crystal contacts and provides an assessment of how the biologically relevant interfaces combine into a biological assembly. EPPIC takes a fundamentally different approach than PISA, and it should be seen as complementary to PISA. The authors suggest combining to improve biological assembly assignments.

===Software: Probable Quaternary Structure Server (PQS)===

Biological Unit: Difference between revisions

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@@ Line 116: / Line 116: @@
 The [http://www.ebi.ac.uk/msd-srv/prot_int/pistart.html Protein Interfaces, Surfaces and Assemblies Server] (PISA) at the European Bioinformatics Institute uses improved methods to predict the biological unit or probable quaternary assembly, compared to its predecessor PQS (see next section). These servers examine the contacts that occur in macromolecular crystals used in [[X-ray crystallography]]. They attempt to discriminate between [[crystal contacts]] (artifacts of crystallization) and contacts between chains that have co-evolved to maintain specific oligomeric binding.
+===Software: Evolutionary Protein-Protein Interface Classifier (EPPIC)===
+The [https://www.eppic-web.org/ewui/ Evolutionary Protein Protein Interface Classifier Server] (EPPIC) classifies all protein-protein contacts in crystal lattices as biologically relevant or crystal contacts and provides an assessment of how the biologically relevant interfaces combine into a biological assembly. EPPIC takes a fundamentally different approach than PISA, and it should be seen as complementary to PISA. The authors suggest combining to improve biological assembly assignments.
 ===Software: Probable Quaternary Structure Server (PQS)===