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| <StructureSection load='' size='350' side='right' caption='E. coli transketolase 1 dimer complex with xylulose-5-phosphate-thiamine diphosphate adduct, ethylene glycol and Ca+2 ion (green) (PDB code [[2r8o]]).' scene='46/466534/Cv/1'> | | <StructureSection load='' size='350' side='right' caption='E. coli transketolase 1 dimer complex with xylulose-5-phosphate-thiamine diphosphate adduct, ethylene glycol and Ca+2 ion (green) (PDB code [[2r8o]]).' scene='46/466534/Cv/1'> |
| _TOC_
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| == Function == | | == Function == |
| '''Transketolase''' (TKT) catalyzes two opposite reactions. The synthesis of sedoheptulose-7-P in the pentose phosphate pathway using thiamine diphosphate (TPP) as co-factor; and the conversion of sedoheptulose-7-P and glyceraldehyde-3-P to aldose and ketose in the Calvin cycle<ref>PMID:8369276</ref>. '''Split-gene TKT''' is found in the hyperthermophilic bacterium ''Carboxydothermus hydrogenoformans'' and is reconstituted from 2 separate polypeptide chains<ref>PMID:33193259</ref>. | | '''Transketolase''' (TKT) catalyzes two opposite reactions. The synthesis of sedoheptulose-7-P in the pentose phosphate pathway using thiamine diphosphate (TPP) as co-factor; and the conversion of sedoheptulose-7-P and glyceraldehyde-3-P to aldose and ketose in the Calvin cycle<ref>PMID:8369276</ref>. '''Split-gene TKT''' is found in the hyperthermophilic bacterium ''Carboxydothermus hydrogenoformans'' and is reconstituted from 2 separate polypeptide chains<ref>PMID:33193259</ref>. |
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| The <scene name='46/466534/Cv/7'>active site of TKT contains a ligand-cofactor adduct</scene>.<ref>PMID:17914867</ref> Water molecules are shown as red spheres. <scene name='46/466534/Cv/8'>Ca coordination site</scene>. | | The <scene name='46/466534/Cv/7'>active site of TKT contains a ligand-cofactor adduct</scene>.<ref>PMID:17914867</ref> Water molecules are shown as red spheres. <scene name='46/466534/Cv/8'>Ca coordination site</scene>. |
| [[Transketolase 3D structures]]
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| </StructureSection>
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| == 3D Structures of transketolase == | | == 3D Structures of transketolase == |
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
| | [[Transketolase 3D structures]] |
| {{#tree:id=OrganizedByTopic|openlevels=0|
| | </StructureSection> |
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| * Transketolase
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| **[[1trk]] – yTKT – yeast
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| **[[1ay0]] – yTKT (mutant)
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| **[[2e6k]] – TKT – ''Thermus thermophilus''
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| **[[3hyl]] – BaTKT – ''Bacillus anthracis''
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| **[[3kom]] – TKT (mutant) – ''Francisella tularensis''
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| **[[3l84]] – CjTKT – ''Campylobacter jejuni''<br />
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| **[[3rim]] – TKT – ''Mycobacterium tuberculosis''<br />
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| **[[3uk1]] – BtTKT – ''Burkholderia thailandensis''<br />
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| **[[4c7v]] - LsTKT – ''Lactobacillus salivarius''<br />
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| **[[4xeu]] - TKT – ''Pseudomonas aeruginosa''<br />
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| **[[5i4i]], [[5xry]] - PsTKT – ''Pichia stipitis''<br />
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| **[[5hgx]], [[5i5g]] - PsTKT (mutant)<br />
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| **[[5nd6]] - CrTKT – ''Chlamydomonas reinhardtii''<br />
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| **[[5vrb]] - TKT – ''Neisseria gonorrhoeae''<br />
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| **[[6rjc]] - EcTKT 1 – ''Escherichia coli''<br />
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| *Transketolase binary complexes
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| **[[3mos]], [[3ooy]] – hTKT + TPP - human<br />
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| **[[4kxy]] - hTKT + TPP analog<br />
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| **[[6ha3]] - hTKT (mutant) + fructose phosphate/TPP<br />
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| **[[6had]], [[6rjb]] - hTKT (mutant) + TDP<br />
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| **[[1itz]] - TKT + TPP – maize
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| **[[1tka]], [[1tkb]], [[1tkc]] – yTKT + TPP analog
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| **[[1gpu]] - yTKT 1 + TPP derivative
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| **[[1qgd]] - EcTKT + TPP <br />
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| **[[6tj8]] - EcTKT 1 + TPP analog <br />
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| **[[5hht]] - EcTKT (mutant) + TDP <br />
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| **[[1r9j]] - TKT + TPP – ''Leishmania mexicana''<br />
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| **[[4c7x]] - LsTKT + TPP <br />
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| **[[5hyv]], [[5x56]], [[5xuf]], [[5xvt]], [[5xs6]] - PsTKT + TPP <br />
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| **[[5xsa]], [[5xsb]], [[5xsm]], [[5xt0]], [[5xt4]], [[5xtv]], [[5xtx]] - PsTKT + TPP intermediate<br />
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| **[[5xqk]] - PsTKT + xylulose-5-P<br />
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| **[[5xqa]] - PsTKT + ribose-5-P<br />
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| **[[5xps]] - PsTKT + erythrose-4-P<br />
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| **[[5xrv]] - PsTKT + fructose-6-P<br />
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| **[[5i51]] - PsTKT (mutant) + fructose-6-P<br />
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| **[[5xtl]] - PsTKT + pyrimidine derivative <br />
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| **[[5nd5]] - CrTKT + TPP <br />
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| **[[3m49]] – BaTKT + TPP<br />
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| *Transketolase ternary complexes
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| **[[4kxu]] - hTKT + TPP + sorbitol 6-P<br />
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| **[[4kxv]], [[4kxw]] - hTKT + TPP + xylitol 5-P<br />
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| **[[4kxx]] - hTKT + TPP + seduheptulose 7-P<br />
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| **[[1ngs]] - yTKT + TPP + Ca + erythrose-4-P<br />
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| **[[3m7i]], [[3m6l]] – CjTKT + TPP + ribose 5-P
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| **[[3m34]] - CjTKT + TPP + Ca
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| **[[2r5n]] – EcTKT 1 + TPP + ribose 5-P<br />
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| **[[3upt]],[[5xqa]] - BtTKT + TPP + ribose 5-P<br />
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| **[[2r8o]], [[5xqk]] - EcTKT 1 + TPP + xylulose 5-P<br />
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| **[[6tj9]] - EcTKT 1 + TPP analog + xylulose 5-P<br />
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| **[[2r8p]] - EcTKT 1 + TPP + fructose 6-P<br />
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| **[[5hje]] - PsTKT + TPP + seduheptulose 7-P<br />
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| **[[5i51]], [[5xrv]], [[5xu2]] - PsTKT + TPP + fructose 6-P<br />
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| **[[5xps]], [[5xu9]] - PsTKT + TPP + erythrose 4-P<br />
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| **[[5i5e]] - PsTKT (mutant) + TPP + xylulose 5-P<br />
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| *Split-gene transketolase
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| **[[6yak]] - ChTKT N-terminal + C-terminal chain – ''Carboxydothermus hydrogenoformans''<br />
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| **[[6yaj]] - ChTKT C-terminal chain<br />
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| }}
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| == References == | | == References == |
| <references/> | | <references/> |
| [[Category:Topic Page]] | | [[Category:Topic Page]] |
