7szz: Difference between revisions
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==Structure of the smaller diameter PSMalpha3 nanotubes== | ==Structure of the smaller diameter PSMalpha3 nanotubes== | ||
<StructureSection load='7szz' size='340' side='right'caption='[[7szz]]' scene=''> | <StructureSection load='7szz' size='340' side='right'caption='[[7szz]], [[Resolution|resolution]] 3.90Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7SZZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7SZZ FirstGlance]. <br> | <table><tr><td colspan='2'>[[7szz]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7SZZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7SZZ FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7szz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7szz OCA], [https://pdbe.org/7szz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7szz RCSB], [https://www.ebi.ac.uk/pdbsum/7szz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7szz ProSAT]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7szz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7szz OCA], [https://pdbe.org/7szz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7szz RCSB], [https://www.ebi.ac.uk/pdbsum/7szz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7szz ProSAT]</span></td></tr> | ||
</table> | </table> | ||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
SignificanceThe formation of cross-alpha amyloids has been shown by crystallographic analysis of the highly cytolytic peptide PSMalpha3, a secreted virulence factor associated with the human pathogen Staphylococcus aureus. However, the relationship of the crystallographic cross-alpha structure to self-assembled filaments of PSMalpha3 and its relevance to other phenol-soluble modulin (PSM) peptides remained an open question. We report the cryo-electron microscopy structural analysis of three nanotubes derived from self-assembly of PSMalpha3 and PSMbeta2 peptides in aqueous solution. In each case, the nanotubes are derived from self-association of cross-alpha amyloid protofilaments. The self-assembly behavior of S. aureus PSMalpha3 and PSMbeta2 peptides provides strong evidence for the importance of the cross-alpha fold in self-assembled peptide and protein structures in general and for PSMs in particular. | |||
Phenol-soluble modulins PSMalpha3 and PSMbeta2 form nanotubes that are cross-alpha amyloids.,Kreutzberger MAB, Wang S, Beltran LC, Tuachi A, Zuo X, Egelman EH, Conticello VP Proc Natl Acad Sci U S A. 2022 May 17;119(20):e2121586119. doi:, 10.1073/pnas.2121586119. Epub 2022 May 9. PMID:35533283<ref>PMID:35533283</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 7szz" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Beltran | [[Category: Beltran, L C]] | ||
[[Category: Conticello | [[Category: Conticello, V P]] | ||
[[Category: Egelman | [[Category: Egelman, E H]] | ||
[[Category: Kreutzberger | [[Category: Kreutzberger, M A]] | ||
[[Category: Wang S]] | [[Category: Wang, S]] | ||
[[Category: Amyloid]] | |||
[[Category: Cross-alpha]] | |||
[[Category: Nanotube]] | |||
[[Category: Protein fibril]] | |||
Revision as of 08:16, 25 May 2022
Structure of the smaller diameter PSMalpha3 nanotubes
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