1h5o: Difference between revisions

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[[Image:1h5o.gif|left|200px]]
{{Seed}}
[[Image:1h5o.png|left|200px]]


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{{STRUCTURE_1h5o|  PDB=1h5o  |  SCENE=  }}  
{{STRUCTURE_1h5o|  PDB=1h5o  |  SCENE=  }}  


'''SOLUTION STRUCTURE OF CROTAMINE, A NEUROTOXIN FROM CROTALUS DURISSUS TERRIFICUS'''
===SOLUTION STRUCTURE OF CROTAMINE, A NEUROTOXIN FROM CROTALUS DURISSUS TERRIFICUS===




==Overview==
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Crotamine is a component of the venom of the snake Crotalus durissus terrificus and it belongs to the myotoxin protein family. It is a 42 amino acid toxin cross-linked by three disulfide bridges and characterized by a mild toxicity (LD50 = 820 micro g per 25 g body weight, i.p. injection) when compared to other members of the same family. Nonetheless, it possesses a wide spectrum of biological functions. In fact, besides being able to specifically modify voltage-sensitive Na+ channel, it has been suggested to exhibit analgesic activity and to be myonecrotic. Here we report its solution structure determined by proton NMR spectroscopy. The secondary structure comprises a short N-terminal alpha-helix and a small antiparallel triple-stranded beta-sheet arranged in an alphabeta1beta2beta3 topology never found among toxins active on ion channels. Interestingly, some scorpion toxins characterized by a biological activity on Na+ channels similar to the one reported for crotamine, exhibit an alpha/beta fold, though with a beta1alphabeta2beta3 topology. In addition, as the antibacterial beta-defensins, crotamine interacts with lipid membranes. A comparison of crotamine with human beta-defensins shows a similar fold and a comparable net positive potential surface. To the best of our knowledge, this is the first report on the structure of a toxin from snake venom active on Na+ channel.
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{{ABSTRACT_PUBMED_12709056}}


==About this Structure==
==About this Structure==
1H5O is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Crotalus_durissus_terrificus Crotalus durissus terrificus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H5O OCA].  
1H5O is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Crotalus_durissus_terrificus Crotalus durissus terrificus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H5O OCA].  


==Reference==
==Reference==
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[[Category: Toxin]]
[[Category: Toxin]]
[[Category: Venom]]
[[Category: Venom]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:27:57 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 06:39:49 2008''

Revision as of 03:39, 1 July 2008

File:1h5o.png

Template:STRUCTURE 1h5o

SOLUTION STRUCTURE OF CROTAMINE, A NEUROTOXIN FROM CROTALUS DURISSUS TERRIFICUS

Template:ABSTRACT PUBMED 12709056

About this Structure

1H5O is a Single protein structure of sequence from Crotalus durissus terrificus. Full experimental information is available from OCA.

Reference

Solution structure of crotamine, a Na+ channel affecting toxin from Crotalus durissus terrificus venom., Nicastro G, Franzoni L, de Chiara C, Mancin AC, Giglio JR, Spisni A, Eur J Biochem. 2003 May;270(9):1969-79. PMID:12709056

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