7zlm: Difference between revisions

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'''Unreleased structure'''


The entry 7zlm is ON HOLD  until Paper Publication
==Crystal structure of SOCS2:ElonginB:ElonginC in complex with compound MN551==
 
<StructureSection load='7zlm' size='340' side='right'caption='[[7zlm]], [[Resolution|resolution]] 1.79&Aring;' scene=''>
Authors: Ramachandran, S., Ciulli, A., Makukhin, N.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[7zlm]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZLM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZLM FirstGlance]. <br>
Description: Crystal structure of SOCS2:ElonginB:ElonginC in complex with compound MN551
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JIH:[4-[(2~{S})-3-[[3-(2-chloranylethanoylamino)phenyl]methylamino]-2-[2-(4-fluorophenyl)ethanoylamino]-3-oxidanylidene-propyl]phenyl]+dihydrogen+phosphate'>JIH</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zlm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zlm OCA], [https://pdbe.org/7zlm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zlm RCSB], [https://www.ebi.ac.uk/pdbsum/7zlm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zlm ProSAT]</span></td></tr>
[[Category: Ciulli, A]]
</table>
[[Category: Ramachandran, S]]
== Function ==
[[Category: Makukhin, N]]
[https://www.uniprot.org/uniprot/SOCS2_HUMAN SOCS2_HUMAN] SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Ciulli A]]
[[Category: Makukhin N]]
[[Category: Ramachandran S]]
Retrieved from "https://proteopedia.org/7zlm"