7zlp: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 7zlp is ~~ON HOLD until Paper Publication~~

==Crystal structure of SOCS2:ElonginB:ElonginC in complex with compound 9==

~~Authors~~: ~~Ramachandran~~, S., ~~Ciulli~~, A., ~~Makukhin~~, N.

== Structural highlights ==

<table><tr><td colspan='2'>[[7zlp]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZLP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZLP FirstGlance]. <br>

~~Description~~: ~~Crystal structure~~ of SOCS2~~:ElonginB:ElonginC~~ in complex ~~with compound 9~~

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JHR:[4-[(2~{S})-2-[2-(4-fluorophenyl)ethanoylamino]-3-[(4-fluorophenyl)methylamino]-3-oxidanylidene-propyl]phenyl]+dihydrogen+phosphate'>JHR</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zlp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zlp OCA], [https://pdbe.org/7zlp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zlp RCSB], [https://www.ebi.ac.uk/pdbsum/7zlp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zlp ProSAT]</span></td></tr>

[[Category: Ciulli, A]]

</table>

[[Category: ~~Ramachandran, S~~]]

== Function ==

[[Category: ~~Makukhin, N~~]]

[https://www.uniprot.org/uniprot/SOCS2_HUMAN SOCS2_HUMAN] SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Ciulli A]]

[[Category: Makukhin N]]

[[Category: Ramachandran S]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 7zlp is ON HOLD  until Paper Publication
+==Crystal structure of SOCS2:ElonginB:ElonginC in complex with compound 9==
+<StructureSection load='7zlp' size='340' side='right'caption='[[7zlp]], [[Resolution|resolution]] 1.94&Aring;' scene=''>
-Authors: Ramachandran, S., Ciulli, A., Makukhin, N.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[7zlp]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZLP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZLP FirstGlance]. <br>
-Description: Crystal structure of SOCS2:ElonginB:ElonginC in complex with compound 9
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JHR:[4-[(2~{S})-2-[2-(4-fluorophenyl)ethanoylamino]-3-[(4-fluorophenyl)methylamino]-3-oxidanylidene-propyl]phenyl]+dihydrogen+phosphate'>JHR</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zlp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zlp OCA], [https://pdbe.org/7zlp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zlp RCSB], [https://www.ebi.ac.uk/pdbsum/7zlp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zlp ProSAT]</span></td></tr>
-[[Category: Ciulli, A]]
+</table>
-[[Category: Ramachandran, S]]
+== Function ==
-[[Category: Makukhin, N]]
+[https://www.uniprot.org/uniprot/SOCS2_HUMAN SOCS2_HUMAN] SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Ciulli A]]
+[[Category: Makukhin N]]
+[[Category: Ramachandran S]]